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HLA haplotypes and long survival in childhood acute lymphoblastic leukaemia treated with transfer factor.

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De Bruyère, Marc [UCL] Cornu, Guy [UCL] Heremans-Bracke, T Malchaire, Jacques [UCL] Sokal, G. [UCL]

Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their relatives, it is suggested that children possessing A2 B12 or A2 B40 haplotypes may respond better to this type of immunotherapy.

Document type Article de périodique (Journal article) – Journal Article
Publication date 1980
Journal information "British journal of haematology" - Vol. 44, no. 2, p. 243-51 (1980)
Peer reviewed yes
issn 0007-1048
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/ESP - Ecole de santé publique
MESH Subject Acute Disease ; Adolescent ; Child ; Child, Preschool ; Cytotoxicity Tests, Immunologic ; Female ; HLA Antigens - genetics - immunology ; Haploidy ; Humans ; Infant ; Infant, Newborn ; Leukemia, Lymphoid - drug therapy - genetics - immunology ; Male ; Prognosis ; Time Factors ; Transfer Factor - therapeutic use
Links
Bibliographic reference De Bruyère, Marc ; Cornu, Guy ; Heremans-Bracke, T ; Malchaire, Jacques ; Sokal, G.. HLA haplotypes and long survival in childhood acute lymphoblastic leukaemia treated with transfer factor.. In: British journal of haematology, Vol. 44, no. 2, p. 243-51 (1980)
Permanent URL http://hdl.handle.net/2078.1/22597