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Distinct Role of FAK Kinase and C-Terminal Domains on Small-Cell Lung Cancer Proliferation [P3.15-004]

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Aboubakar Nana, Frank [UCL] Lecocq, Marylène [UCL] Ladjemi, Maha [UCL] Detry, Bruno [UCL] Dupasquier, Sébastien [UCL] Sibille, Yves [UCL] Pilette, Charles [UCL] Ocak, Sebahat [UCL]

Small-cell lung cancer (SCLC) is a devastating illness with a median five-year overall survival of 5%. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed/activated in many cancers, including SCLC. We hypothesized that FAK overexpression/activation in SCLC contributes to its aggressive behavior and that FAK may represent a novel therapeutic target in SCLC.

Document type Communication à un colloque (Conference Paper) – Poster, Abstract
Publication date 2017
Language Anglais
Conference "IASLC 18th World Conference on Lung Cancer", (Japan) Yokohama (du 15/10/2017 au 18/10/2017)
Journal information "Journal of Thoracic Oncology" - Vol. 12, no.11, p. S2339 (2017)
Peer reviewed yes
issn 1556-0864
e-issn 1556-1380
Publisher Elsevier ((United Kingdom) London)
Publication status Publié
Affiliations UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - (MGD) Service de pneumologie
UCL - (SLuc) Service de pneumologie
Links
Bibliographic reference Aboubakar Nana, Frank ; Lecocq, Marylène ; Ladjemi, Maha ; Detry, Bruno ; Dupasquier, Sébastien ; et. al. Distinct Role of FAK Kinase and C-Terminal Domains on Small-Cell Lung Cancer Proliferation [P3.15-004].IASLC 18th World Conference on Lung Cancer ((Japan) Yokohama, du 15/10/2017 au 18/10/2017). In: Journal of Thoracic Oncology, Vol. 12, no.11, p. S2339 (2017)
Permanent URL http://hdl.handle.net/2078.1/240593