More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.

Parma, Valentina Ohla, Kathrin Veldhuizen, Maria G Niv, Masha Y Kelly, Christine E Bakke, Alyssa J Cooper, Keiland W Bouysset, Cédric Pirastu, Nicola Dibattista, Michele Kaur, Rishemjit Liuzza, Marco Tullio Pepino, Marta Y Schöpf, Veronika Pereda-Loth, Veronica Olsson, Shannon B Gerkin, Richard C Rohlfs Domínguez, Paloma Albayay, Javier Farruggia, Michael C Bhutani, Surabhi Fjaeldstad, Alexander W Kumar, Ritesh Menini, Anna Bensafi, Moustafa Sandell, Mari Konstantinidis, Iordanis Di Pizio, Antonella Genovese, Federica Öztürk, Lina Thomas-Danguin, Thierry Frasnelli, Johannes Boesveldt, Sanne Saatci, Özlem Saraiva, Luis R Lin, Cailu Golebiowski, Jérôme Hwang, Liang-Dar Ozdener, Mehmet Hakan Guàrdia, Maria Dolors Laudamiel, Christophe Ritchie, Marina Havlícek, Jan Pierron, Denis Roura, Eugeni Navarro, Marta Nolden, Alissa A Lim, Juyun Whitcroft, Katherine L Colquitt, Lauren R Ferdenzi, Camille Brindha, Evelyn V Altundag, Aytug Macchi, Alberto Nunez-Parra, Alexia Patel, Zara M Fiorucci, Sébastien Philpott, Carl M Smith, Barry C Lundström, Johan N Mucignat, Carla Parker, Jane K van den Brink, Mirjam Schmuker, Michael Fischmeister, Florian Ph S Heinbockel, Thomas Shields, Vonnie D C Faraji, Farhoud Santamaría, Enrique Fredborg, William E A Morini, Gabriella Olofsson, Jonas K Jalessi, Maryam Karni, Noam D'Errico, Anna Alizadeh, Rafieh Pellegrino, Robert Meyer, Pablo Huart, Caroline [UCL] Chen, Ben Soler, Graciela M Alwashahi, Mohammed K Welge-Lüssen, Antje Freiherr, Jessica de Groot, Jasper H B Klein, Hadar Okamoto, Masako Singh, Preet Bano Hsieh, Julien W GCCR Group Author Reed, Danielle R Hummel, Thomas Munger, Steven D Hayes, John E et al.[show all]

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

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Document type	Article de périodique (Journal article) – Article de recherche
Access type	Accès libre
Publication date	2020
Language	Anglais
Journal information	"Chemical senses" - Vol. 45, no.7, p. 609-622 (2020)
Peer reviewed	yes
Publisher	Oxford University Press ((United Kingdom) Oxford)
issn	0379-864X
e-issn	1464-3553
Publication status	Publié
Affiliations	UCL - SSS/IONS - Institute of NeuroScience UCL - SSS/IONS/NEUR - Clinical Neuroscience UCL - (SLuc) Service d'oto-rhino-laryngologie
MESH Subject	Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Male ; Middle Aged ; Olfaction Disorders ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Self Report ; Smell ; Somatosensory Disorders ; Surveys and Questionnaires ; Taste ; Taste Disorders ; Young Adult
Keywords	head and neck surgery ; olfaction ; somatosensation
Links	https://www.ncbi.nlm.nih.gov/pubmed/32564071[Pubmed] https://doi.org/10.1093/chemse/bjaa041[DOI] http://hdl.handle.net/2078.1/261966[Handle]

See also
	[boreal:261967]	Corrigendum to: More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.