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Automated digital quantification of parenchymal lung fibrosis in COVID-19 related and -unrelated ARDS

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Gérard, Ludovic [UCL]

1) PSR staining allows robust and reliable quantification of collagen deposition in human lung tissue and allows to distinguish between « compact » (old) and « scattered » (young) collagen fibers 2) Total CPA (all collagen fibers) increases in ARDS compared to controls No difference between COVID-related and COVID-unrelated ARDS 3) Dramatic increase of « scattered » (young) fibers in all ARDS patients, with no significant difference between COVID-related or -unrelated ARDS 4) Scattered fibers correlate with disease severity in all ARDS patients No correlation with disease/MV duration

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Access type Accès libre
Publication date 2022
Language Anglais
Conference "Congrès de la Société Belge de Soins intensifs SIZ" (15/06/2020)
Affiliation UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
Keywords COVID ; ARDS ; Lung ; Fibrosis
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Bibliographic reference Gérard, Ludovic ; et. al. Automated digital quantification of parenchymal lung fibrosis in COVID-19 related and -unrelated ARDS.Congrès de la Société Belge de Soins intensifs SIZ (15/06/2020).
Permanent URL http://hdl.handle.net/2078.1/273759