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The influence of liver disease on the methylation of arsenite in humans.

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Buchet, Jean-Pierre [UCL] Geubel, André Pauwels, Stanislas Mahieu, P. Lauwerys, Robert [UCL]

The capacity for inorganic arsenic (ASi) methylation in 13 healthy volunteers and in 30 patients with different types of liver disease has been assessed by measuring the amount of unmetabolized ASi, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) excreted in urine within 24 h after the IV injection of 7.14 micrograms/kg ASi. Liver disease does not affect the percent of the injected dose excreted within 24 h but has striking and opposite effects on the proportions of MMA and DMA. MMA excretion is highly correlated with the 14C-aminopyrine breath test (r = 0.73; P less than 0.05). The reduction in the proportion of MMA excreted in urine and the increase in that of DMA are similar with regard to sensitivity and specificity for detecting liver impairment. Unlike the 14C-aminopyrine breath test, the inorganic arsenic methylation test offers the advantage of being unaffected by treatment with microsomal enzyme inducers.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1984
Journal information "Archives of toxicology" - Vol. 55, no. 3, p. 151-4 (1984)
Peer reviewed yes
issn 0340-5761
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
MESH Subject Adult ; Aminopyrine - metabolism ; Arsenic - metabolism ; Arsenicals - urine ; Arsenites ; Female ; Humans ; Liver Diseases - metabolism ; Liver Function Tests ; Male ; Methylation ; Middle Aged ; Phenobarbital - pharmacology
Links
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  2. Buchet JP, Lauwerys R, Roels H (1981a) Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethyl arsonate or dimethylarsinate in man. Int Arch Occup Environ Health 48:71?79
  3. Buchet JP, Lauwerys R, Roels H (1981b) Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers. Int Arch Occup Environ Health 48:111?118
  4. Crecelius E (1977) Changes in the chemical speciation of arsenic following ingestion by man. Environ Health Perspect 19:147?150
  5. Lauwerys R, Buchet JP, Roels H (1979) The determination of trace levels of arsenic in human biological materials. Arch Toxicol 41:239?247
  6. Mahieu P, Buchet JP, Roels H, Lauwerys R (1981) The metabolism of arsenic in humans acutely intoxicated by As2O3. Its significance for the duration of BAL therapy. Clin Toxicol 18:1067?1075
  7. Pauwels S, Geubel AP, Dive C, Beckers C (1982) Breath 14CO2 after intravenous administration of 14C-aminopyrine in liver diseases. Dig Dis Sciences 127:49?56
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  10. Tseng WP, Chu HM, How SW, Fong JM, Lin CS, Yeh S (1968) Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst 40:453?463
Bibliographic reference Buchet, Jean-Pierre ; Geubel, André ; Pauwels, Stanislas ; Mahieu, P. ; Lauwerys, Robert. The influence of liver disease on the methylation of arsenite in humans.. In: Archives of toxicology, Vol. 55, no. 3, p. 151-4 (1984)
Permanent URL http://hdl.handle.net/2078.1/27915