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Rapid emergence of multimarker strategies in laboratory medicine.

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Gruson, Damien [UCL] Bodovitz, S

A single biomarker has an inherent specificity and sensitivity that cannot be improved, but multiple biomarkers can be combined to achieve improved clinical performances. This is the basis of multimarker strategies that integrate different biomarkers into a single score to support medical decisions. The simplest strategy determines ratios of different biomarkers or the number of different markers above their respective thresholds. A more advanced strategy employs similar biomarkers, but uses more sophisticated algorithms. The most advanced strategy employs large numbers of biomarkers that may or may not have been previously characterized and uses sophisticated algorithms.

Document type Article de périodique (Journal article) – Journal Article
Publication date 2010
Journal information "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals" - Vol. 15, no. 4, p. 289-96 (2010)
Peer reviewed yes
issn 1354-750X
e-issn 1366-5804
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL
MESH Subject Technology, Medical - methods ; Reverse Transcriptase Polymerase Chain Reaction ; Microarray Analysis ; Mass Spectrometry ; Humans ; Disease ; Diagnosis ; Biological Markers - analysis
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  1. Amonkar Suraj D., Bertenshaw Greg P., Chen Tzong-Hao, Bergstrom Katharine J., Zhao Jinghua, Seshaiah Partha, Yip Ping, Mansfield Brian C., Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer, 10.1371/journal.pone.0004599
  2. Apple F. S., Smith S. W., Pearce L. A., Murakami M. M., Assessment of the Multiple-Biomarker Approach for Diagnosis of Myocardial Infarction in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome, 10.1373/clinchem.2008.102905
  3. Arant Christopher B., Wessel Timothy R., Ridker Paul M., Olson Marian B., Reis Steven E., Delia Johnson B., Sharaf Barry L., Pauly Daniel F., Handberg Eileen, Zineh Issam, Sopko George, Kelsey Sheryl F., Noel Bairey Merz C., Pepine Carl J., Multimarker Approach Predicts Adverse Cardiovascular Events in Women Evaluated for Suspected Ischemia: Results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation, 10.1002/clc.20454
  4. Boutros P. C., Lau S. K., Pintilie M., Liu N., Shepherd F. A., Der S. D., Tsao M.-S., Penn L. Z., Jurisica I., Prognostic gene signatures for non-small-cell lung cancer, 10.1073/pnas.0809444106
  5. Campbell D. J., Nussberger J., Stowasser M., Danser A.H. J., Morganti A., Frandsen E., Menard J., Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement, 10.1373/clinchem.2008.118000
  6. Cronin M., Sangli C., Liu M.-L., Pho M., Dutta D., Nguyen A., Jeong J., Wu J., Langone K. C., Watson D., Analytical Validation of the Oncotype DX Genomic Diagnostic Test for Recurrence Prognosis and Therapeutic Response Prediction in Node-Negative, Estrogen Receptor-Positive Breast Cancer, 10.1373/clinchem.2006.076497
  7. Fagan Anne M., Roe Catherine M., Xiong Chengjie, Mintun Mark A., Morris John C., Holtzman David M., Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults, 10.1001/archneur.64.3.noc60123
  8. Fan Cheng, Oh Daniel S., Wessels Lodewyk, Weigelt Britta, Nuyten Dimitry S.A., Nobel Andrew B., van't Veer Laura J., Perou Charles M., Concordance among Gene-Expression–Based Predictors for Breast Cancer, 10.1056/nejmoa052933
  9. Glas Annuska M, Floore Arno, Delahaye Leonie JMJ, Witteveen Anke T, Pover Rob CF, Bakx Niels, Lahti-Domenici Jaana ST, Bruinsma Tako J, Warmoes Marc O, Bernards René, Wessels Lodewyk FA, Van 't Veer Laura J, 10.1186/1471-2164-7-278
  10. Halfon Philippe, Munteanu Mona, Poynard Thierry, FibroTest-ActiTest as a non-invasive marker of liver fibrosis, 10.1016/s0399-8320(08)73991-5
  11. Hansson Oskar, Zetterberg Henrik, Buchhave Peder, Londos Elisabet, Blennow Kaj, Minthon Lennart, Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study, 10.1016/s1474-4422(06)70355-6
  12. Harima Yoko, Ikeda Koshi, Utsunomiya Keita, Shiga Toshiko, Komemushi Atsushi, Kojima Hiroyuki, Nomura Motoo, Kamata Minoru, Sawada Satoshi, Identification of Genes Associated With Progression and Metastasis of Advanced Cervical Cancers After Radiotherapy by cDNA Microarray Analysis, 10.1016/j.ijrobp.2009.07.002
  13. Ikonomidis Ignatios, Stamatelopoulos Kimon, Lekakis John, Vamvakou Georgia D., Kremastinos Dimitrios Th, Inflammatory and non-invasive vascular markers: The multimarker approach for risk stratification in coronary artery disease, 10.1016/j.atherosclerosis.2008.02.019
  14. Kavsak P. A., Ko D. T., Newman A. M., Palomaki G. E., Lustig V., MacRae A. R., Jaffe A. S., Risk Stratification for Heart Failure and Death in an Acute Coronary Syndrome Population Using Inflammatory Cytokines and N-Terminal Pro-Brain Natriuretic Peptide, 10.1373/clinchem.2007.090613
  15. Le Calvez Sophie, Thabut Dominique, Messous Djamila, Munteanu Mona, Ratziu Vlad, Imbert-Bismut Francoise, Poynard Thierry, The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C, 10.1002/hep.20099
  16. Lieb W., Larson M. G., Benjamin E. J., Yin X., Tofler G. H., Selhub J., Jacques P. F., Wang T. J., Vita J. A., Levy D., Vasan R. S., Mitchell G. F., Multimarker Approach to Evaluate Correlates of Vascular Stiffness: The Framingham Heart Study, 10.1161/circulationaha.108.816108
  17. Lindahl B., Multimarker Approach for Diagnosis of Acute Myocardial Infarction: Better Answers Need Better Questions, 10.1373/clinchem.2008.117572
  18. Linkov F., Lisovich A., Yurkovetsky Z., Marrangoni A., Velikokhatnaya L., Nolen B., Winans M., Bigbee W., Siegfried J., Lokshin A., Ferris R. L., Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Multiplexed Immunobead-Based Biomarker Profiling, 10.1158/1055-9965.epi-06-0602
  19. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C., Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man, 10.1007/bf00280883
  20. McCann Conor J., Glover Ben M., Menown Ian B.A., Moore Michael J., McEneny Jane, Owens Colum G., Smith Bernie, Sharpe Peter C., Young Ian S., Adgey Jennifer A., Prognostic Value of a Multimarker Approach for Patients Presenting to Hospital With Acute Chest Pain, 10.1016/j.amjcard.2008.08.026
  21. Melander Olle, Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community, 10.1001/jama.2009.943
  22. Möckel Martin, Danne Oliver, Müller Reinhold, Vollert Jörn O., Müller Christian, Lueders Christian, Störk Thomas, Frei Ulrich, Koenig Wolfgang, Dietz Rainer, Jaffe Allan S., Development of an optimized multimarker strategy for early risk assessment of patients with acute coronary syndromes, 10.1016/j.cca.2008.03.022
  23. Moore Richard G., McMeekin D. Scott, Brown Amy K., DiSilvestro Paul, Miller M. Craig, Allard W. Jeffrey, Gajewski Walter, Kurman Robert, Bast Robert C., Skates Steven J., A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass, 10.1016/j.ygyno.2008.08.031
  24. Mulatero Paolo, Stowasser Michael, Loh Keh-Chuan, Fardella Carlos E., Gordon Richard D., Mosso Lorena, Gomez-Sanchez Celso E., Veglio Franco, Young William F., Increased Diagnosis of Primary Aldosteronism, Including Surgically Correctable Forms, in Centers from Five Continents, 10.1210/jc.2003-031337
  25. Paik Soonmyung, Shak Steven, Tang Gong, Kim Chungyeul, Baker Joffre, Cronin Maureen, Baehner Frederick L., Walker Michael G., Watson Drew, Park Taesung, Hiller William, Fisher Edwin R., Wickerham D. Lawrence, Bryant John, Wolmark Norman, A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer, 10.1056/nejmoa041588
  26. Paik Soonmyung, Tang Gong, Shak Steven, Kim Chungyeul, Baker Joffre, Kim Wanseop, Cronin Maureen, Baehner Frederick L., Watson Drew, Bryant John, Costantino Joseph P., Geyer Charles E., Wickerham D. Lawrence, Wolmark Norman, Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer, 10.1200/jco.2005.04.7985
  27. Pepe M. S., Feng Z., Huang Y., Longton G., Prentice R., Thompson I. M., Zheng Y., Integrating the Predictiveness of a Marker with Its Performance as a Classifier, 10.1093/aje/kwm305
  28. Poynard T., Prospective Analysis of Discordant Results between Biochemical Markers and Biopsy in Patients with Chronic Hepatitis C, 10.1373/clinchem.2004.032227
  29. Ridker Paul M, Buring Julie E., Rifai Nader, Cook Nancy R., Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women : The Reynolds Risk Score, 10.1001/jama.297.6.611
  30. Ridker P. M, Paynter N. P., Rifai N., Gaziano J. M., Cook N. R., C-Reactive Protein and Parental History Improve Global Cardiovascular Risk Prediction: The Reynolds Risk Score for Men, 10.1161/circulationaha.108.814251
  31. Roberts Chris, McNamee Roseanne, Assessing the reliability of ordered categorical scales using kappa-type statistics, 10.1191/0962280205sm413oa
  32. Sabatine M. S., Multimarker Approach to Risk Stratification in Non-ST Elevation Acute Coronary Syndromes: Simultaneous Assessment of Troponin I, C-Reactive Protein, and B-Type Natriuretic Peptide, 10.1161/01.cir.0000015464.18023.0a
  33. Sepehri Amir A., Hancq Joel, Dutoit Thierry, Gharehbaghi Arash, Kocharian Armen, Kiani A., Computerized screening of children congenital heart diseases, 10.1016/j.cmpb.2008.06.015
  34. Sheu Chau-Chyun, Chang Mei-Yin, Chang Huang-Chou, Tsai Jong-Rung, Lin Shiu-Ru, Chang Shun-Jen, Hwang Jhi-Jhu, Huang Ming-Shyan, Chong Inn-Wen, Combined Detection of CEA, CK-19 and c-met mRNAs in Peripheral Blood: A Highly Sensitive Panel for Potential Molecular Diagnosis of Non-Small Cell Lung Cancer, 10.1159/000094321
  35. Slodkowska Elzbieta A, Ross Jeffrey S, MammaPrint™ 70-gene signature: another milestone in personalized medical care for breast cancer patients, 10.1586/erm.09.32
  36. Sunami E., Shinozaki M., Higano C. S., Wollman R., Dorff T. B., Tucker S. J., Martinez S. R., Singer F. R., Hoon D. S.B., Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients, 10.1373/clinchem.2008.108498
  37. Wang Thomas J., Gona Philimon, Larson Martin G., Tofler Geoffrey H., Levy Daniel, Newton-Cheh Christopher, Jacques Paul F., Rifai Nader, Selhub Jacob, Robins Sander J., Benjamin Emelia J., D'Agostino Ralph B., Vasan Ramachandran S., Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death, 10.1056/nejmoa055373
  38. Zairis MN, Int J Cardiol (2009)
  39. Zethelius Björn, Berglund Lars, Sundström Johan, Ingelsson Erik, Basu Samar, Larsson Anders, Venge Per, Ärnlöv Johan, Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes, 10.1056/nejmoa0707064
  40. Ziol Marianne, Handra-Luca Adriana, Kettaneh Adrien, Christidis Christos, Mal Frédéric, Kazemi Farhad, de Lédinghen Victor, Marcellin Patrick, Dhumeaux Daniel, Trinchet Jean-Claude, Beaugrand Michel, Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C, 10.1002/hep.20506
Bibliographic reference Gruson, Damien ; Bodovitz, S. Rapid emergence of multimarker strategies in laboratory medicine.. In: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 15, no. 4, p. 289-96 (2010)
Permanent URL http://hdl.handle.net/2078.1/29148