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Feasibility of (90)Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres.

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Lhommel, Renaud [UCL] Van Elmbt, Larry [UCL] Goffette, Pierre [UCL] Van den Eynde, Marc [UCL] Jamar, François [UCL] Pauwels, Stanislas [UCL] Walrand, Stéphan [UCL]

PURPOSE: (90)Y-labelled compounds used in targeted radiotherapy are usually imaged with SPECT by recording the bremsstrahlung X-rays of the beta decay. The continuous shape of the X-ray spectrum induces the presence of a significant fraction of scatter rays in the acquisition energy window, reducing the accuracy of biodistribution and of dosimetry assessments. METHODS: The aim of this paper is to use instead the low branch of e(-) e(+) pair production in the (90)Y decay. After administration of (90)Y-labelled SIR-Spheres by catheterization of both liver lobes, the activity distribution is obtained by (90)Y time-of-flight (TOF) PET imaging. The activity distribution is convolved with a dose irradiation kernel in order to derive the regional dosimetry distribution. RESULTS: Evaluation on an anatomical phantom showed that the method provided an accurate dosimetry assessment. Preliminary results on a patient demonstrated a high-resolution absorbed dose distribution with a clear correlation with tumour response. CONCLUSION: This supports the implementation of (90)Y PET in selective internal radiation therapy of the liver.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "European Journal of Nuclear Medicine and Molecular Imaging" - Vol. 37, no. 9, p. 1654-1662 (2010)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 1619-7070
e-issn 1619-7089
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IONS - Institute of NeuroScience
UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - Service de gastro-entérologie
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Service de médecine nucléaire
UCL - (SLuc) Service de radiologie
UCL - (SLuc) Unité d'oncologie médicale
MESH Subject Yttrium Radioisotopes - diagnostic use - pharmacokinetics ; Time Factors ; Reproducibility of Results ; Radiotherapy Dosage ; Radiometry - methods ; Positron-Emission Tomography ; Phantoms, Imaging ; Neoplasm Metastasis ; Middle Aged ; Microspheres ; Liver Neoplasms - metabolism - radionuclide imaging - radiotherapy - secondary ; Linear Models ; Humans ; Female ; Feasibility Studies
Keywords (90)Y ; Pet imaging ; SIRT ; Dosimetry ; Microspheres
Links
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Bibliographic reference Lhommel, Renaud ; Van Elmbt, Larry ; Goffette, Pierre ; Van den Eynde, Marc ; Jamar, François ; et. al. Feasibility of (90)Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres.. In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 37, no. 9, p. 1654-1662 (2010)
Permanent URL http://hdl.handle.net/2078.1/32171