User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

Primary tabs

Raina, Sheetal De Vizio, Daniela Odell, Mark Clements, Mark Vanhulle, Sophie [UCL] Keshavarz, Tajalli

Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing. Originally discovered in Gram-negative bacteria, quorum-sensing systems have also been studied extensively in Gram-positive bacteria and dimorphic fungi. Microbial communities communicating via quorum sensing employ various chemical signals to supervise their surrounding environment, alter genetic expression and gain advantage over their competitors. These signals vary from acylhomoserine lactones to small modified or unmodified peptides to complex gamma-butyrolactone molecules. The scope of this review is to give an insight into some of the quorum-sensing systems now known and to explore their role in microbial physiology and development of pathogenesis. Particular attention will be dedicated to the signalling molecules involved in quorum-sensing-mediated processes and the potential shown by some of their natural and synthetic analogues in the treatment of infections triggered by quorum sensing.

Document type Article de périodique (Journal article) – Synthèse de littérature
Publication date 2009
Language Anglais
Journal information "Biotechnology and Applied Biochemistry" - Vol. 54, p. 65-84 (2009)
Peer reviewed yes
Publisher Portland Press Ltd (London)
issn 0885-4513
e-issn 1470-8744
Publication status Publié
Affiliation UCL
Keywords acylhomoserine lactone (AHL) ; autoinducer ; butyrolactones ; furanones ; quorum sensing ; signal transduction
Links
  1. Fuqua W, J. Bacteriol., 176, 269 (1994)
  2. Nealson K, J. Bacteriol., 104, 313 (1970)
  3. Greenberg E. Peter, Bacterial communication and group behavior, 10.1172/jci200320099
  4. Surette M. G., Bassler B. L., Quorum sensing in Escherichia coli and Salmonella typhimurium, 10.1073/pnas.95.12.7046
  5. Swift S, Adv. Microb. Physiol., 45, 199 (2001)
  6. Eberhard A., Burlingame A. L., Eberhard C., Kenyon G. L., Nealson K. H., Oppenheimer N. J., Structural identification of autoinducer of Photobacterium fischeri luciferase, 10.1021/bi00512a013
  7. Engebrecht Joanne, Nealson Kenneth, Silverman Michael, Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri, 10.1016/0092-8674(83)90063-6
  8. Withers Helen, Swift Simon, Williams Paul, Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria, 10.1016/s1369-5274(00)00187-9
  9. Miller Melissa B., Bassler Bonnie L., Quorum Sensing in Bacteria, 10.1146/annurev.micro.55.1.165
  10. Bassler Bonnie L, How bacteria talk to each other: regulation of gene expression by quorum sensing, 10.1016/s1369-5274(99)00025-9
  11. Kleerebezem Michiel, Quadri Luis E. N., Kuipers Oscar P., de Vos Willem M., Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria, 10.1046/j.1365-2958.1997.4251782.x
  12. Bassler Bonnie L, Small Talk, 10.1016/s0092-8674(02)00749-3
  13. Parkinson J
  14. Dunny Gary M., Leonard Bettina A. B., CELL-CELL COMMUNICATION IN GRAM-POSITIVE BACTERIA, 10.1146/annurev.micro.51.1.527
  15. Miller V L, Mekalanos J J, A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR., 10.1128/jb.170.6.2575-2583.1988
  16. Gambello M, J. Bacteriol., 173, 3000 (1991)
  17. Throup John P., Camara Miguel, Briggs Geoffrey S., Winson Michael. K., Chhabra Siri Ram, Bycroft Barrie W., Williams Paul, Stewart Gordon S.A.B., Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N-acylhomoserine lactone signal molecules, 10.1111/j.1365-2958.1995.mmi_17020345.x
  18. Pesci E, J. Bacteriol., 179, 3127 (1997)
  19. Lewenza S, J. Bacteriol., 181, 748 (1999)
  20. Passador L, Cook J., Gambello M., Rust L, Iglewski B., Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication, 10.1126/science.8493556
  21. Winson M. K., Camara M., Latifi A., Foglino M., Chhabra S. R., Daykin M., Bally M., Chapon V., Salmond G. P., Bycroft B. W., Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa., 10.1073/pnas.92.20.9427
  22. Davies D. G., The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm, 10.1126/science.280.5361.295
  23. Yoon Sang Sun, Hennigan Robert F., Hilliard George M., Ochsner Urs A., Parvatiyar Kislay, Kamani Moneesha C., Allen Holly L., DeKievit Teresa R., Gardner Paul R., Schwab Ute, Rowe John J., Iglewski Barbara H., McDermott Timothy R., Mason Ronald P., Wozniak Daniel J., Hancock Robert E.W., Parsek Matthew R., Noah Terry L., Boucher Richard C., Hassett Daniel J., Pseudomonas aeruginosa Anaerobic Respiration in Biofilms, 10.1016/s1534-5807(02)00295-2
  24. Hentzer Morten, Eberl Leo, Nielsen John, Givskov Michael, Quorum Sensing : A Novel Target for the Treatment of Biofilm Infections, 10.2165/00063030-200317040-00003
  25. Wagner V. E., Bushnell D., Passador L., Brooks A. I., Iglewski B. H., Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment, 10.1128/jb.185.7.2080-2095.2003
  26. Schuster M., Lostroh C. P., Ogi T., Greenberg E. P., Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis, 10.1128/jb.185.7.2066-2079.2003
  27. Whiteley M., Lee K. M., Greenberg E. P., Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa, 10.1073/pnas.96.24.13904
  28. Hentzer M
  29. Gambello M, Infect. Immun., 61, 1180 (1993)
  30. Pearson J. P., Gray K. M., Passador L., Tucker K. D., Eberhard A., Iglewski B. H., Greenberg E. P., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes., 10.1073/pnas.91.1.197
  31. Latifi A., Foglino M., Tanaka K., Williams P., Lazdunski A., A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS, 10.1046/j.1365-2958.1996.00063.x
  32. Ochsner U, J. Biol. Chem., 269, 19787 (1994)
  33. Ochsner U. A., Reiser J., Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa., 10.1073/pnas.92.14.6424
  34. Pearson J. P., Passador L., Iglewski B. H., Greenberg E. P., A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa., 10.1073/pnas.92.5.1490
  35. Ochsner U, J. Bacteriol., 176, 2044 (1994)
  36. Cabrol S., Olliver A., Pier G. B., Andremont A., Ruimy R., Transcription of Quorum-Sensing System Genes in Clinical and Environmental Isolates of Pseudomonas aeruginosa, 10.1128/jb.185.24.7222-7230.2003
  37. Smith E. E., Buckley D. G., Wu Z., Saenphimmachak C., Hoffman L. R., D'Argenio D. A., Miller S. I., Ramsey B. W., Speert D. P., Moskowitz S. M., Burns J. L., Kaul R., Olson M. V., Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients, 10.1073/pnas.0602138103
  38. Duan K., Surette M. G., Environmental Regulation of Pseudomonas aeruginosa PAO1 Las and Rhl Quorum-Sensing Systems, 10.1128/jb.00043-07
  39. Venturi Vittorio, Regulation of quorum sensing inPseudomonas, 10.1111/j.1574-6976.2005.00012.x
  40. Tang H, Infect. Immun., 64, 37 (1996)
  41. Rumbaugh K, Infect. Immun., 67, 5854 (1999)
  42. Wu Hong, Heydorn Arne, Eberl Leo, Song Zhijun, Hentzer Morten, Molin Søren, Givskov Michael, Moser Claus, Mathee Kalai, Høiby Niels, Andersen Jens Bo, Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa, 10.1099/00221287-146-10-2481
  43. Tan M.-W., Mahajan-Miklos S., Ausubel F. M., Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis, 10.1073/pnas.96.2.715
  44. Rumbaugh Kendra P., Diggle Stephen P., Watters Chase M., Ross-Gillespie Adin, Griffin Ashleigh S., West Stuart A., Quorum Sensing and the Social Evolution of Bacterial Virulence, 10.1016/j.cub.2009.01.050
  45. Chugani S. A., Whiteley M., Lee K. M., D'Argenio D., Manoil C., Greenberg E. P., QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa, 10.1073/pnas.051624298
  46. Ledgham Fouzia, Ventre Isabelle, Soscia Chantal, Foglino Maryline, Sturgis James N., Lazdunski Andrée, Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR : Interactions of QscR, 10.1046/j.1365-2958.2003.03423.x
  47. Juhas M., Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa, 10.1099/mic.0.26906-0
  48. Diggle Stephen P., Winzer Klaus, Chhabra Siri Ram, Worrall Kathryn E., Cámara Miguel, Williams Paul, The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR : PQS regulation of rhl-dependent phenotypes, 10.1046/j.1365-2958.2003.03672.x
  49. Pesci E. C., Milbank J. B. J., Pearson J. P., McKnight S., Kende A. S., Greenberg E. P., Iglewski B. H., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa, 10.1073/pnas.96.20.11229
  50. Smith Roger S., Iglewski Barbara H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, 10.1172/jci200320364
  51. TATEDA Kazuhiro, ISHII Yoshikazu, YAMAGUCHI Keizo, , 10.3412/jsb.59.543
  52. Giacometti A., Cirioni O., Gov Y., Ghiselli R., Del Prete M. S., Mocchegiani F., Saba V., Orlando F., Scalise G., Balaban N., Dell'Acqua G., RNA III Inhibiting Peptide Inhibits In Vivo Biofilm Formation by Drug-Resistant Staphylococcus aureus, 10.1128/aac.47.6.1979-1983.2003
  53. Lowy Franklin D., Staphylococcus aureusInfections, 10.1056/nejm199808203390806
  54. Mehlin Christopher, Headley Catherine M., Klebanoff Seymour J., An Inflammatory Polypeptide Complex fromStaphylococcus epidermidis: Isolation and Characterization, 10.1084/jem.189.6.907
  55. Balaban N., Novick R. P., Autocrine regulation of toxin synthesis by Staphylococcus aureus., 10.1073/pnas.92.5.1619
  56. Morfeldt E, EMBO J., 14, 4569 (1995)
  57. Novick R. P., Projan S. J., Kornblum J., Ross H. F., Ji G., Kreiswirth B., Vandenesch F., Moghazeh S., Novick R. P., Theagr P2 operon: An autocatalytic sensory transduction system inStaphylococcus aureus, 10.1007/bf02191645
  58. Ji G., Beavis R. C., Novick R. P., Cell density control of staphylococcal virulence mediated by an octapeptide pheromone., 10.1073/pnas.92.26.12055
  59. Mayville P., Ji G., Beavis R., Yang H., Goger M., Novick R. P., Muir T. W., Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence, 10.1073/pnas.96.4.1218
  60. Otto Michael, Süßmuth Roderich, Jung Günther, Götz Friedrich, Structure of the pheromone peptide of theStaphylococcus epidermidis agrsystem, 10.1016/s0014-5793(98)00145-8
  61. Saenz Henri L., Augsburger Vera, Vuong Cuong, Jack Ralph W., Götz Friedrich, Otto Michael, Inducible expression and cellular location of AgrB, a protein involved in the maturation of the staphylococcal quorum-sensing pheromone, 10.1007/s002030000223
  62. Zhang Linsheng, Lin Jianqun, Ji Guangyong, Membrane Anchoring of the AgrD N-terminal Amphipathic Region Is Required for Its Processing to Produce a Quorum-sensing Pheromone inStaphylococcus aureus, 10.1074/jbc.m311349200
  63. Otto Michael, Süßmuth Roderich, Vuong Cuong, Jung Günther, Götz Friedrich, Inhibition of virulence factor expression inStaphylococcus aureusby theStaphylococcus epidermidisagr pheromone and derivatives, 10.1016/s0014-5793(99)00514-1
  64. Koenig R. L., Ray J. L., Maleki S. J., Smeltzer M. S., Hurlburt B. K., Staphylococcus aureus AgrA Binding to the RNAIII-agr Regulatory Region, 10.1128/jb.186.22.7549-7555.2004
  65. Huntzinger Eric, Boisset Sandrine, Saveanu Cosmin, Benito Yvonne, Geissmann Thomas, Namane Abdelkader, Lina Gérard, Etienne Jerome, Ehresmann Bernard, Ehresmann Chantal, Jacquier Alain, Vandenesch François, Romby Pascale, Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression, 10.1038/sj.emboj.7600572
  66. Novick Richard P., Geisinger Edward, Quorum Sensing in Staphylococci, 10.1146/annurev.genet.42.110807.091640
  67. Novick Richard P., Autoinduction and signal transduction in the regulation of staphylococcal virulence : Regulation of staphylococcus virulence, 10.1046/j.1365-2958.2003.03526.x
  68. Otto Michael, Quorum-sensing control in Staphylococci – a target for antimicrobial drug therapy?, 10.1016/j.femsle.2004.11.016
  69. Vuong Cuong, Dürr Manuela, Carmody Aaron B., Peschel Andreas, Klebanoff  Seymour J., Otto Michael, Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins : Quorum sensing control of inflammation in S. epidermidis, 10.1111/j.1462-5822.2004.00401.x
  70. Yang G, Inhibition of Staphylococcus aureus pathogenesis in vitro and in vivo by RAP-binding peptides, 10.1016/j.peptides.2003.09.017
  71. Yarwood J. M., Bartels D. J., Volper E. M., Greenberg E. P., Quorum Sensing in Staphylococcus aureus Biofilms, 10.1128/jb.186.6.1838-1850.2004
  72. Klapwijk P, J. Bacteriol., 136, 775 (1978)
  73. Ellis J. G., Kerr A., Petit A., Tempe J., Conjugal transfer of nopaline and agropine Ti-plasmids ?The role of agrocinopines, 10.1007/bf00331861
  74. Habeeb Linda F., Transcription of the Octopine Catabolism Operon of theAgrobacteriumTumor-Inducing Plasmid pTiA6 Is Activated by a LysR-Type Regulatory Protein, 10.1094/mpmi-4-379
  75. Wang Lu, Helmann John D., Winans Stephen C., The A. tumefaciens transcriptional activator OccR causes a bend at a target promoter, which is partially relaxed by a plant tumor metabolite, 10.1016/0092-8674(92)90229-6
  76. Fuqua Clay, Winans Stephen C., Localization of OccR-activated and TraR-activated promoters that express two ABC-type permeases and the traR gene of Ti plasmid pTiR10, 10.1111/j.1365-2958.1996.tb02640.x
  77. Piper Kevin R., Beck von Bodman Susanne, Hwang Ingyu, Farrand Stephen K., Hierarchical gene regulatory systems arising from fortuitous gene associations: controlling quorum sensing by the opine regulon in Agrobacterium, 10.1046/j.1365-2958.1999.01422.x
  78. More M. I., Finger L. D., Stryker J. L., Fuqua C., Eberhard A., Winans S. C., Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates, 10.1126/science.272.5268.1655
  79. Beck von Bodman S., Hayman G. T., Farrand S. K., Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor., 10.1073/pnas.89.2.643
  80. Kim H, J. Bacteriol., 179, 7559 (1997)
  81. Fuqua C, J. Bacteriol., 177, 1367 (1995)
  82. Hwang I, J. Bacteriol., 177, 449 (1995)
  83. Hwang Ingyu, Smyth Audra J., Luo Zhao-Qing, Farrand Stephen K., Modulating quorum sensing by antiactivation: TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes, 10.1046/j.1365-2958.1999.01595.x
  84. Luo Zhao-Qing, Qin Yinping, Farrand Stephen K., The Antiactivator TraM Interferes with the Autoinducer-dependent Binding of TraR to DNA by Interacting with the C-terminal Region of the Quorum-sensing Activator, 10.1074/jbc.275.11.7713
  85. Piper K. R., Farrand S. K., Quorum Sensing but Not Autoinduction of Ti Plasmid Conjugal Transfer Requires Control by the Opine Regulon and the Antiactivator TraM, 10.1128/jb.182.4.1080-1088.2000
  86. Perombelon M C M, Kelman A, Ecology of the Soft Rot Erwinias, 10.1146/annurev.py.18.090180.002045
  87. Demain A, Int. Microbiol., 1, 259 (1998)
  88. Quadri Luis E.N., 10.1023/a:1020624808520
  89. Vandenbergh Peter A., Lactic acid bacteria, their metabolic products and interference with microbial growth, 10.1111/j.1574-6976.1993.tb00020.x
  90. Buchman G, J. Biol. Chem., 263, 16260 (1988)
  91. Engelke G, Appl. Environ. Microbiol., 58, 3730 (1992)
  92. Kaletta C, Entian K D, Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product., 10.1128/jb.171.3.1597-1601.1989
  93. KUIPERS Oscar P., BEERTHUYZEN Marke M., SIEZEN Roland J., VOS Willem M., Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisIgenes for development of immunity, 10.1111/j.1432-1033.1993.tb18143.x
  94. Siegers K, Appl. Environ. Microbiol., 61, 1082 (1995)
  95. van der Meer J, J. Bacteriol., 175, 2578 (1993)
  96. Engelke G, Appl. Environ. Microbiol., 60, 814 (1994)
  97. Stock Jeffry B., Stock Ann M., Mottonen James M., Signal transduction in bacteria, 10.1038/344395a0
  98. Parkinson John S., Kofoid Eric C., Communication Modules in Bacterial Signaling Proteins, 10.1146/annurev.ge.26.120192.000443
  99. Wanner B, J. Bacteriol., 174, 2053 (1992)
  100. Gross E, Hoppe-Seylers Z. Physiol. Chem., 354, 799 (1973)
  101. Gutowski-Eckel Z, Appl. Environ. Microbiol., 60, 1 (1994)
  102. Klein C, Appl. Environ. Microbiol., 59, 296 (1993)
  103. McGowan Simon J., Holden Matthew T. G., Bycroft Barrie W., Salmond George P. C., 10.1023/a:1001768428383
  104. Salmond G. P. C., Bycroft B. W., Stewart G. S. A. B., Williams P., The bacterial 'enigma': cracking the code of cell?cell communication, 10.1111/j.1365-2958.1995.tb02424.x
  105. Bibb Mervyn J, Regulation of secondary metabolism in streptomycetes, 10.1016/j.mib.2005.02.016
  106. Collmer A, Keen N T, The Role of Pectic Enzymes in Plant Pathogenesis, 10.1146/annurev.py.24.090186.002123
  107. Byers J. T., Lucas C., Salmond G. P. C., Welch M., Nonenzymatic Turnover of an Erwinia carotovora Quorum-Sensing Signaling Molecule, 10.1128/jb.184.4.1163-1171.2002
  108. Jones S, EMBO J., 12, 2477 (1993)
  109. Fineran P, Mol. Microbiol., 56, 1495 (2005)
  110. Gerber Nancy N., Lechevalier Mary P., Phenazines and Phenoxaziones from Waksmania aerata sp. nov. and Pseudomonas iodina*, 10.1021/bi00892a022
  111. Karnetová J., Tax J., Stajner K., Vaněk Z., Krumphanzl V., Production of phenazines byStreptomyces cinnamonensis, 10.1007/bf02877385
  112. Giddens Stephen R., Bean David C., Investigations into the in vitro antimicrobial activity and mode of action of the phenazine antibiotic d-alanylgriseoluteic acid, 10.1016/j.ijantimicag.2006.08.028
  113. Pierson III Leland S., Cloning and Heterologous Expression of the Phenazine Biosynthetic Locus fromPseudomonas aureofaciens30-84, 10.1094/mpmi-5-330
  114. Wood D, J. Bacteriol., 179, 7663 (1997)
  115. Chin-A-Woeng Thomas F. C., Bloemberg Guido V., Mulders Ine H. M., Dekkers Linda C., Lugtenberg Ben J. J., Root Colonization by Phenazine-1-Carboxamide-Producing BacteriumPseudomonas chlororaphisPCL1391 Is Essential for Biocontrol of Tomato Foot and Root Rot, 10.1094/mpmi.2000.13.12.1340
  116. Chin-A-Woeng Thomas F. C., van den Broek Daan, de Voer Gert, van der Drift Koen M. G. M., Tuinman Sietske, Thomas-Oates Jane E., Lugtenberg Ben J. J., Bloemberg Guido V., Phenazine-1-Carboxamide Production in the Biocontrol StrainPseudomonas chlororaphisPCL1391 Is Regulated by Multiple Factors Secreted into the Growth Medium, 10.1094/mpmi.2001.14.8.969
  117. Horinouchi S, Beppu T, Autoregulatory Factors and Communication in Actinomycetes, 10.1146/annurev.mi.46.100192.002113
  118. Miyake K, J. Bacteriol., 171, 4298 (1989)
  119. Recio E., Colinas A., Rumbero A., Aparicio J. F., Martin J. F., PI Factor, a Novel Type Quorum-sensing Inducer Elicits Pimaricin Production in Streptomyces natalensis, 10.1074/jbc.m402340200
  120. OHNISHI Yasuo, YAMAZAKI Haruka, KATO Jun-ya, TOMONO Ayami, HORINOUCHI Sueharu, AdpA, a Central Transcriptional Regulator in the A-Factor Regulatory Cascade That Leads to Morphological Development and Secondary Metabolism inStreptomyces griseus, 10.1271/bbb.69.431
  121. Natsume Ryo, Ohnishi Yasuo, Senda Toshiya, Horinouchi Sueharu, Crystal Structure of a γ-Butyrolactone Autoregulator Receptor Protein in Streptomyces coelicolor A3(2), 10.1016/j.jmb.2003.12.040
  122. Nihira T
  123. Kitani S., Yamada Y., Nihira T., Gene Replacement Analysis of the Butyrolactone Autoregulator Receptor (FarA) Reveals that FarA Acts as a Novel Regulator in Secondary Metabolism of Streptomyces lavendulae FRI-5, 10.1128/jb.183.14.4357-4363.2001
  124. Takano Eriko, Chakraburtty Rekha, Nihira Takuya, Yamada Yashuhiro, Bibb Mervyn J., A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2) : γ-Butyrolactones and antibiotic production, 10.1046/j.1365-2958.2001.02562.x
  125. Wietzorrek Andreas, Bibb Mervyn, A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold, 10.1046/j.1365-2958.1997.5421903.x
  126. Recio E., Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes, 10.1099/mic.0.28953-0
  127. Anton N., Mendes M. V., Martin J. F., Aparicio J. F., Identification of PimR as a Positive Regulator of Pimaricin Biosynthesis in Streptomyces natalensis, 10.1128/jb.186.9.2567-2575.2004
  128. Marketon M. M., Glenn S. A., Eberhard A., Gonzalez J. E., Quorum Sensing Controls Exopolysaccharide Production in Sinorhizobium meliloti, 10.1128/jb.185.1.325-331.2003
  129. von Bodman S. B., Majerczak D. R., Coplin D. L., A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii, 10.1073/pnas.95.13.7687
  130. Xavier Karina B., Bassler Bonnie L., Interference with AI-2-mediated bacterial cell–cell communication, 10.1038/nature03960
  131. Bassler B, J. Bacteriol., 179, 4043 (1997)
  132. Surette M. G., Miller M. B., Bassler B. L., Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production, 10.1073/pnas.96.4.1639
  133. Schauder Stephan, Shokat Kevan, Surette Michael G., Bassler Bonnie L., The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule : AI-2 biosynthesis, 10.1046/j.1365-2958.2001.02532.x
  134. Bassler Bonnie L., Wright Miriam, Silverman Michael R., Multiple signalling systems controlling expression of luminescence in Vibrio harveyi : sequence and function of genes encoding a second sensory pathway, 10.1111/j.1365-2958.1994.tb00422.x
  135. Bassler Bonnie L., Wright Miriam, Silverman Michael R., Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi, 10.1111/j.1365-2958.1994.tb01029.x
  136. Freeman Jeremy A., Bassler Bonnie L., A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi, 10.1046/j.1365-2958.1999.01208.x
  137. Martin M, Showalter R, Silverman M, Identification of a locus controlling expression of luminescence genes in Vibrio harveyi., 10.1128/jb.171.5.2406-2414.1989
  138. Showalter R, J. Bacteriol., 172, 2946 (1990)
  139. Long Tao, Tu Kimberly C, Wang Yufang, Mehta Pankaj, Ong N. P, Bassler Bonnie L, Wingreen Ned S, Quantifying the Integration of Quorum-Sensing Signals with Single-Cell Resolution, 10.1371/journal.pbio.1000068
  140. Wang L., Li J., March J. C., Valdes J. J., Bentley W. E., luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling, 10.1128/jb.187.24.8350-8360.2005
  141. DeLisa M. P., Wu C.-F., Wang L., Valdes J. J., Bentley W. E., DNA Microarray-Based Identification of Genes Controlled by Autoinducer 2-Stimulated Quorum Sensing in Escherichia coli, 10.1128/jb.183.18.5239-5247.2001
  142. Sperandio V., Mellies J. L., Nguyen W., Shin S., Kaper J. B., Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli, 10.1073/pnas.96.26.15196
  143. Burgess Nicola A., Aduse-Opoku Joseph, Cámara Miguel, Winzer Klaus, Williams Paul, Meyers Nicholas L., Curtis Michael A., Kirke David F., Hardie Kim R., LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence, 10.1099/00221287-148-3-763
  144. Chung W. O., Park Y., Lamont R. J., McNab R., Barbieri B., Demuth D. R., Signaling System in Porphyromonas gingivalis Based on a LuxS Protein, 10.1128/jb.183.13.3903-3909.2001
  145. Fong K. P., Chung W. O., Lamont R. J., Demuth D. R., Intra- and Interspecies Regulation of Gene Expression by Actinobacillus actinomycetemcomitans LuxS, 10.1128/iai.69.12.7625-7634.2001
  146. McNab R., Ford S. K., El-Sabaeny A., Barbieri B., Cook G. S., Lamont R. J., LuxS-Based Signaling in Streptococcus gordonii: Autoinducer 2 Controls Carbohydrate Metabolism and Biofilm Formation with Porphyromonas gingivalis, 10.1128/jb.185.1.274-284.2003
  147. Taga Michiko E., Semmelhack Julia L., Bassler Bonnie L., The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium : Autoinducer-dependent gene regulation, 10.1046/j.1365-2958.2001.02669.x
  148. Taga Michiko E., Miller Stephen T., Bassler Bonnie L., Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium : Transport and processing of AI-2, 10.1046/j.1365-2958.2003.03781.x
  149. Miller Melissa B., Skorupski Karen, Lenz Derrick H., Taylor Ronald K., Bassler Bonnie L., Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae, 10.1016/s0092-8674(02)00829-2
  150. Zhu J., Miller M. B., Vance R. E., Dziejman M., Bassler B. L., Mekalanos J. J., Quorum-sensing regulators control virulence gene expression in Vibrio cholerae, 10.1073/pnas.052694299
  151. Finkelstein R, Infect. Immun., 60, 472 (1992)
  152. Lyon William R., Madden John C., Levin James C., Stein Jeffrey L., Caparon Michael G., Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes : The effect of LuxS on virulence factors in S. pyogenes, 10.1046/j.1365-2958.2001.02616.x
  153. Ohtani Kaori, Hayashi Hideo, Shimizu Tohru, The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens : luxS gene function in C. perfringens toxin production, 10.1046/j.1365-2958.2002.02863.x
  154. Jones M. B., Blaser M. J., Detection of a luxS-Signaling Molecule in Bacillus anthracis, 10.1128/iai.71.7.3914-3919.2003
  155. Auger S., Krin E., Aymerich S., Gohar M., Autoinducer 2 Affects Biofilm Formation by Bacillus cereus, 10.1128/aem.72.1.937-941.2006
  156. Hilgers M. T., Ludwig M. L., Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site, 10.1073/pnas.191223098
  157. Ruzheinikov S.N, Das S.K, Sedelnikova S.E, Hartley A, Foster S.J, Horsburgh M.J, Cox A.G, McCleod C.W, Mekhalfia A, Blackburn G.M, Rice D.W, Baker P.J, The 1.2 Å structure of a novel quorum-sensing protein, Bacillus subtilis LuxS 1 1Edited by J. Thornton, 10.1006/jmbi.2001.5027
  158. Winzer K, Bacterial cell-to-cell communication: sorry, can't talk now — gone to lunch!, 10.1016/s1369-5274(02)00304-1
  159. Pei Dehua, Zhu Jinge, Mechanism of action of S-ribosylhomocysteinase (LuxS), 10.1016/j.cbpa.2004.08.003
  160. Lombardia E., Rovetto A. J., Arabolaza A. L., Grau R. R., A LuxS-Dependent Cell-to-Cell Language Regulates Social Behavior and Development in Bacillus subtilis, 10.1128/jb.00165-06
  161. Chu Frances, Kearns Daniel B., Branda Steven S., Kolter Roberto, Losick Richard, Targets of the master regulator of biofilm formation in Bacillus subtilis, 10.1111/j.1365-2958.2005.05019.x
  162. Hamon Mélanie A., Lazazzera Beth A., The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis : Biofilm development in Bacillus subtilis, 10.1046/j.1365-2958.2001.02709.x
  163. Hartman Giles, Wise Richard, Quorum sensing: potential means of treating gram-negative infections?, 10.1016/s0140-6736(05)70282-8
  164. Hentzer Morten, Givskov Michael, Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, 10.1172/jci20074
  165. Riedel Kathrin, Steidle Anette, Eberl Leo, Wu Hong, Geisenberger Otto, Molin Søren, Huber Birgit, Hentzer Morten, Høiby Niels, Givskov Michael, N-Acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms, 10.1099/00221287-147-12-3249
  166. Roche D. M., Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?, 10.1099/mic.0.26977-0
  167. Dong Y.-H., Gusti A. R., Zhang Q., Xu J.-L., Zhang L.-H., Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species, 10.1128/aem.68.4.1754-1759.2002
  168. Leadbetter J. R., Greenberg E. P., Metabolism of Acyl-Homoserine Lactone Quorum-Sensing Signals by Variovorax paradoxus, 10.1128/jb.182.24.6921-6926.2000
  169. Liu Dali, Momb Jessica, Thomas Pei W., Moulin Aaron, Petsko Gregory A., Fast Walter, Ringe Dagmar, Mechanism of the Quorum-Quenching Lactonase (AiiA) fromBacillus thuringiensis. 1. Product-Bound Structures†‡, 10.1021/bi800368y
  170. Dong Y.-H., Zhang X.-F., Xu J.-L., Zhang L.-H., Insecticidal Bacillus thuringiensis Silences Erwinia carotovora Virulence by a New Form of Microbial Antagonism, Signal Interference, 10.1128/aem.70.2.954-960.2004
  171. Xu Xiao-Hong Nancy, Wan Qian, Kyriacou Sophia V., Brownlow William J., Nowak Michelle E., Direct observation of substrate induction of resistance mechanism in Pseudomonas aeruginosa using single live cell imaging, 10.1016/s0006-291x(03)00874-x
  172. Smith Kristina M., Bu Yigong, Suga Hiroaki, Library Screening for Synthetic Agonists and Antagonists of a Pseudomonas aeruginosa Autoinducer, 10.1016/s1074-5521(03)00107-8
  173. Smith Kristina M, Bu Yigong, Suga Hiroaki, Induction and Inhibition of Pseudomonas aeruginosa Quorum Sensing by Synthetic Autoinducer Analogs, 10.1016/s1074-5521(03)00002-4
  174. Ikeda T, Chem. Lett., 30, 314 (2001)
  175. Ishida T., Ikeda T., Takiguchi N., Kuroda A., Ohtake H., Kato J., Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides, 10.1128/aem.02233-06
  176. Kim Cheoljin, Kim Jaeeun, Park Hyung-Yeon, Park Hee-Jin, Lee Joon Hee, Kim Chan Kyung, Yoon Jeyong, Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa, 10.1007/s00253-008-1474-6
  177. Kim C, Appl. Microbiol. Biotechnol. (2009)
  178. Morohoshi T., Shiono T., Takidouchi K., Kato M., Kato N., Kato J., Ikeda T., Inhibition of Quorum Sensing in Serratia marcescens AS-1 by Synthetic Analogs of N-Acylhomoserine Lactone, 10.1128/aem.00593-07
  179. Swift S, Infect. Immun., 67, 5192 (1999)
  180. Qin Yinping, Luo Zhao-Qing, Farrand Stephen K., Domains Formed within the N-terminal Region of the Quorumsensing Activator TraR Are Required for Transcriptional Activation and Direct Interaction with RpoA fromAgrobacterium, 10.1074/jbc.m405299200
  181. Zhu J, J. Bacteriol., 180, 5398 (1998)
  182. Reverchon Sylvie, Chantegrel Bernard, Deshayes Christian, Doutheau Alain, Cotte-Pattat Nicole, New synthetic analogues of N -acyl homoserine lactones as agonists or antagonists of transcriptional regulators involved in bacterial quorum sensing, 10.1016/s0960-894x(02)00124-5
  183. Manefield M., de Nys R., Naresh K., Roger R., Givskov M., Peter S., Kjelleberg S., Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein, 10.1099/13500872-145-2-283
  184. Rasmussen Thomas Bovbjerg, Andersen Jens Bo, Eberl Leo, Anthoni Uffe, Christophersen Carsten, Givskov Michael, Steinberg Peter, Manefield Michael, Kjelleberg Staffan, How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1, 10.1099/00221287-146-12-3237
  185. Maximilien R, de Nys R, Holmström C, Gram L, Givskov M, Crass K, Kjelleberg S, Steinberg PD, Chemical mediation of bacterial surface colonisation by secondary metabolites from the red alga Delisea pulchra, 10.3354/ame015233
  186. de Nys Rocky, Wright Anthony D., König Gabriele M., Sticher Otto, New halogenated furanones from the marine alga delisea pulchra (cf. fimbriata), 10.1016/s0040-4020(01)81808-1
  187. Givskov M, J. Bacteriol., 178, 6618 (1996)
  188. Daniels Ruth, Vanderleyden Jos, Michiels Jan, Quorum sensing and swarming migration in bacteria, 10.1016/j.femsre.2003.09.004
  189. Lindum P, J. Bacteriol., 180, 6384 (1998)
  190. Manefield Michael, Steinberg Peter, Rasmussen Thomas Bovbjerg, Henzter Morten, Kjelleberg Staffan, Givskov Michael, Andersen Jens Bo, Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, 10.1099/00221287-148-4-1119
  191. Gram L, Appl. Environ. Microbiol., 62, 4284 (1996)
  192. Ren Dacheng, Sims James J., Wood Thomas K., Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone, 10.1046/j.1462-2920.2001.00249.x
  193. Ren D., Zuo R., Gonzalez Barrios A. F., Bedzyk L. A., Eldridge G. R., Pasmore M. E., Wood T. K., Differential Gene Expression for Investigation of Escherichia coli Biofilm Inhibition by Plant Extract Ursolic Acid, 10.1128/aem.71.7.4022-4034.2005
  194. Hjelmgaard Thomas, Persson Tobias, Rasmussen Thomas B, Givskov Michael, Nielsen John, Synthesis of furanone-Based natural product analogues with quorum sensing antagonist activity, 10.1016/s0968-0896(03)00295-5
  195. Lonn-Stensrud J., Landin M. A., Benneche T., Petersen F. C., Scheie A. A., Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?, 10.1093/jac/dkn501
  196. Wu H., Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, 10.1093/jac/dkh223
  197. Martinelli Daniel, Grossmann Gilles, Séquin Urs, Brandl Helmut, Bachofen Reinhard, 10.1186/1471-2180-4-25
  198. Gonzalez J. E., Marketon M. M., Quorum Sensing in Nitrogen-Fixing Rhizobia, 10.1128/mmbr.67.4.574-592.2003
  199. Loh John, Pierson Elizabeth A, Pierson Leland S, Stacey Gary, Chatterjee Arun, Quorum sensing in plant-associated bacteria, 10.1016/s1369-5266(02)00274-1
  200. Fray Rupert G., Throup John P., Daykin Mavis, Wallace Andrew, Williams Paul, Stewart Gordon S.A.B., Grierson Donald, 10.1038/13717
  201. Mäe Andres, Montesano Marcos, Koiv Viia, Palva E. Tapio, Transgenic Plants Producing the Bacterial PheromoneN-Acyl-Homoserine Lactone Exhibit Enhanced Resistance to the Bacterial PhytopathogenErwinia carotovora, 10.1094/mpmi.2001.14.9.1035
  202. Toth I. K., Newton J. A., Hyman L. J., Lees A. K., Daykin M., Ortori C., Williams P., Fray R. G., Potato Plants Genetically Modified to ProduceN-Acylhomoserine Lactones Increase Susceptibility to Soft Rot Erwiniae, 10.1094/mpmi.2004.17.8.880
  203. Dong Yi-Hu, Wang Lian-Hui, Xu Jin-Ling, Zhang Hai-Bao, Zhang Xi-Fen, Zhang Lian-Hui, Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase, 10.1038/35081101
  204. Zhou Yi, Choi Yong-Lark, Sun Ming, Yu Ziniu, Novel roles of Bacillus thuringiensis to control plant diseases, 10.1007/s00253-008-1610-3
  205. Horowitz Brown S., Zarnowski R., Sharpee W. C., Keller N. P., Morphological Transitions Governed by Density Dependence and Lipoxygenase Activity in Aspergillus flavus, 10.1128/aem.00565-08
  206. Raina S
  207. Keller Laurent, Surette Michael G., Communication in bacteria: an ecological and evolutionary perspective, 10.1038/nrmicro1383
  208. Diggle S. P, Gardner A., West S. A, Griffin A. S, Evolutionary theory of bacterial quorum sensing: when is a signal not a signal?, 10.1098/rstb.2007.2049
  209. Swift S, J. Bacteriol., 179, 5271 (1997)
  210. McGowan S., Sebaihia M., Jones S., Yu B., Bainton N., Chan P. F., Bycroft B., Stewart G.S.A.B., Williams P., Salmond G. P. C., Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator, 10.1099/13500872-141-3-541
  211. Pearson J, J. Bacteriol., 179, 5756 (1997)
Bibliographic reference Raina, Sheetal ; De Vizio, Daniela ; Odell, Mark ; Clements, Mark ; Vanhulle, Sophie ; et. al. Microbial quorum sensing: a tool or a target for antimicrobial therapy?. In: Biotechnology and Applied Biochemistry, Vol. 54, p. 65-84 (2009)
Permanent URL http://hdl.handle.net/2078.1/35236