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Laetrile for cancer: a systematic review of the clinical evidence

  1. http://www.who.int/cancer/media/en/788.pdf
  2. http://216.239.59.104/u/who?q=cache:Pqq2bFQPilgJ:www.euro.who.int/childhealthenv/Risks/CancerTop+children+cancer&hl=en&ie=UTF-8
  3. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_Introduction_7.asp?sitearea
  4. Gibbs M (2004) Networking topics for palliative care. Pharm J 273(7320):539
  5. Schmidt K, Ernst E (2004) Assessing websites on complementary and alternative medicine for cancer. Ann Oncol 15:733–742
  6. Holland JC (1982) Why patients seek unproven cancer remedies: a psychological perspective. CA Cancer J Clin 32(1):10–14
  7. Fenselau C, Pallante S, Batzinger RP, Benson WR, Barron RP, Sheinin EB, Maienthal M (1977) Mandelonitrile beta-glucuronide: synthesis and characterization. Science 198(4317):625–627
  8. Fukuda T, Ito H, Mukainaka T, Tokuda H, Nishino H, Yoshida T (2003) Anti-tumor promoting effect of glycosides from Prunus persica seeds. Biol Pharm Bull 26(2):271–273
  9. Jean Bruneton (1999) Pharmacognosy, 2nd edn. Intercept, Paris
  10. Gurib-Fakim A, Brendler T (2004) Medicinal and aromatic plants of Indian Ocean islands. Medpharm, Stuttgart, Germany
  11. Kwon HY, Hong SP, Hahn DH, Kim JH (2003) Apoptosis induction of Persicae Semen extract in human promyelocytic leukemia (HL-60) cells. Arch Pharm Res 26(2):157–161
  12. Turczan JW, Medwick T, Plank W (1978) Cyanogenetic glycosides. J Assoc Off Anal Chem 61:192–207
  13. Howard-Ruben J, Miller NJ (1984) Unproven methods of cancer management. Part II: current trends and implications for patient care. Oncol Nurs Forum 11(1):67–73
  14. DORR ROBERT T., The Current Status of Laetrile, 10.7326/0003-4819-89-3-389
  15. Davignon JP, Trissel LA, Kleinman LM (1978) Pharmaceutical assessment of amygdalin (laetrile) products. Cancer Treat Rep 62(1):99–104
  16. Ellison NM, Byar DP, Newell GR (1978) Special report on laetrile: NCI (National Cancer Institute) laetrile review. N Engl J Med 299:549–552
  17. David Shaffer (1979) The Associated Press (July 16)
  18. Michael Putzel (1979) The Associated Press (June 19)
  19. 23 states have passed laetrile legislation (1980) The Associated Press (December 21)
  20. Curran WJ (1980) Law-medicine notes. Laetrile for the terminally ill: Supreme Court stops the nonsense. N Engl J Med 302(11):619–621
  21. Meijer EL (2001) Sale over the Internet of substances for human consumption which are regarded as harmful in America. Off J (2001/C 151 E/071)
  22. Questionable cancer practices in Tijuana and other Mexican border clinics (1991). CA Cancer J Clin 41(5):310–319
  23. Moertel CG, Fleming TR, Rubin J, Kvols LK, Sarna G, Koch R, Currie VE, Young CW, Jones SE, Davignon JP (1982) A clinical trial of amygdalin (laetrile) in the treatment of human cancer. N Engl J Med 306(4):201–206
  24. Carter JH, McLafferty MA, Goldman P (1980) Role of the gastrointestinal microflora in amygdalin (laetrile)-induced cyanide toxicity. Biochem Pharmacol 29(3):301–304
  25. Newmark J, Brady RO, Grimley PM, Gal AE, Waller SG, Thistlethwaite JR (1981) Amygdalin (laetrile) and prunasin beta-glucosidases: distribution in germ-free rat and in human tumor tissue. Proc Natl Acad Sci U S A 78(10):6513–6516
  26. Miller KW, Anderson JL, Stoewsand GS (1981) Amygdalin metabolism and effect on reproduction of rats fed apricot (Prunus armeniaca) kernels. J Toxicol Environ Health 7(3–4):457–468
  27. Biaglow JE, Durand RE (1978) The enhanced radiation response of an in vitro tumour model by cyanide released from hydrolysed amygdalin. Int J Radiat Biol Relat Stud Phys Chem Med 33(4):397–401
  28. Manner HW, Di Santi SJ, Maggio MI (1978) Amygdalin, vitamin A and enzyme induced regression of murine mammary adenocarcinomas. J Manip Physiol Ther 1(4):246–248
  29. Bhatti RA, Ablin RJ, Guinan PD (1981) Tumour-associated directed immunity in prostatic cancer: effect of amygdalin. IRCS Med Sci Clin Biochem 9(1):19
  30. Kousparou CA, Epenetos AA, Deonarain MP (2002) Antibody-guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells. Int J Cancer 99(1):138–148 (May 1)
  31. Syrigos KN, Rowlinson-Busza G, Epenetos AA (1998) In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody. Int J Cancer 78(6):712–719
  32. Milazzo S, Ernst E, Lejeune S, Schmidt K (2006) Laetrile treatment for cancer. The Cochrane Database of Systematic Reviews, Issue 2, Art. No.: CD005476
  33. Moertel CG, Ames MM, Kovach JS, Moyer TP, Rubin JR, Tinker JH (1981) Pharmacologic and toxicological study of amygdalin. JAMA 245(6):591–594 (Feb 13)
  34. Ames MM, Moyer TP, Kovach JS, Moertel CG, Rubin J (1981) Pharmacology of amygdalin (laetrile) in cancer patients. Cancer Chemother Pharmacol 6(1):51–57
  35. Schmidt ES, Newton GW, Sanders SM, Lewis JP, Conn EE (1978) Laetrile toxicity studies in dogs. JAMA 239(10):943–947 (Mar 6)
  36. McAnalley BH, Gardiner TH, Garriott JC (1980) Cyanide concentrations in blood after amygdalin (laetrile) administration in rats. Vet Hum Toxicol 22(6):400–402 (Dec)
  37. Treatment of cancer with laetriles; a report by the Cancer Commission of the California Medical Association (1953). Calif Med 78(4):320–326 (Apr)
  38. Guidetti Hector (1955) Observations preliminaries sur quelques cas de cancer traits par un glycuronosyde cyanogenetique. Acta XI(2):156–158
  39. Navarro MD (1957) The mechanism of action and therapeutic effects of laetrile in cancer. J Philipp Med Assoc 33(8):620–627
  40. Tasca M (1959) Clinical observations on the therapeutic effects of a cyanogenetic glycuronoside in cases of human malignant neoplasms. Gazz Med Ital 118(4):153–159 (Apr)
  41. Navarro MD (1964) Laetrile therapy in cancer. Acta Unio Contra Cancrum 20:392–394
  42. Navarro MD (1959) Five years experience with laetrile therapy in advanced cancer. Five years experience with laetrile therapy in advanced cancer. Acta Unio Int Contra Cancrum 15(Suppl 1):209–221
  43. Morrone JA (1962) Chemotherapy of inoperable cancer: preliminary report of 10 cases treated with laetrile. Exp Med Surg 20:299–308
  44. Helvie CO, Cayce CT (1997) Alternative treatment for lung cancer and irregular heartbeat: two case studies. Alternate Health Pract 3(3):185–194
  45. Quackery PP (1992) South Med J 85(2):1264
  46. Mehta P (1980) Ineffectiveness of laetrile in the treatment of acute lymphoblastic leukemia. Clin Pediatr (Phila) 19(5):363–364 (May)
  47. Perspective: resolving an ethical dilemma (1980). Nursing 10(5):39–43
  48. Peterson RG, Rumack BH (1979) Laetrile and pregnancy. Clin Toxicol 15(2):181–184
  49. Campbell DR, Mason WF, Standen JR (1978) Renal arteriography in von Hippel–Lindau disease. J Can Assoc Radiol 29(4):243–246 (Dec)
  50. Ames MM, Kovach JS, Flora KP (1978) Initial pharmacologic studies of amygdalin (laetrile) in man. Res Commun Chem Pathol Pharmacol 22(1):175–185 (Oct)
  51. Reactions to “laetrilomania” (1977). N Engl J Med 297(4):218–221 (Jul 28)
  52. Crippen DW, Veatch RM (1976) Laetrile: cancer cure or quack remedy? Hastings Cent Rep 6(6):18–20 (Dec)
  53. LEOR RON, MICHAELI JOSEPH, BREZIS MEIR, STESSMAN JOCHANAN, Laetrile Intoxication and Hepatic Necrosis: A Possible Association : , 10.1097/00007611-198602000-00034
  54. Beamer WC, Shealy RM, Prough DS (1983) Acute cyanide poisoning from laetrile ingestion. Ann Emerg Med 12(7):449–451 (Jul)
  55. Kalyanaraman UP, Kalyanaraman K, Cullinan SA, McLean JM (1983) Neuromyopathy of cyanide intoxication due to “laetrile” (amygdalin). A clinicopathologic study. Cancer 51(11):2126–2133 (Jun 1)
  56. Shragg TA, Albertson TE, Fisher CJ Jr (1982) Cyanide poisoning after bitter almond ingestion. West J Med 136(1):65–69 (Jan)
  57. Vogel SN, Sultan TR, Ten Eyck RP (1981) Cyanide poisoning. Clin Toxicol 18(3):367–383 (Mar)
  58. Liegner KB, Beck EM, Rosenberg A (1981) Laetrile-induced agranulocytosis. JAMA 246(24):2841–2842 (Dec 18)
  59. Rubino MJ, Davidoff F (1979) Cyanide poisoning from apricot seeds. JAMA 241(4):359 (Jan 26)
  60. Horwitz ET (1979) Of love and laetrile: medical decision making in a child’s best interests. Am J Law Med 5(3):271–294
  61. Morse DL, Boros L, Findley PA (1979) More on cyanide poisoning from laetrile. N Engl J Med 301(16):892 (Oct 18)
  62. Maxwell DM (1978) Increased cyanide values in a laetrile user. Can Med Assoc J 119(1):18 (Jul 8)
  63. Ortega Jorge A., Creek James E., Acute cyanide poisoning following administration of Laetrile enemas, 10.1016/s0022-3476(78)81261-x
  64. Sadoff L, Fuchs K, Hollander J (1978) Rapid death associated with laetrile ingestion. JAMA 239(15):1532 (Apr 14)
  65. Smith FP, Butler TP, Cohan S, Schein PS (1977) Laetrile toxicity: a report of two cases. JAMA 238(13):1361
  66. Navarro MD (1955) Metastatic pulmonary carcinoma treated with laetrile. Unitas 28:606–618
  67. Navarro MD, Lagman CL (1957) Breast carcinoma with lung and bone metastases treated with laetrile; case report. J Philipp Med Assoc 33(1):16–20 (Jan)
  68. Bromley J, Hughes BG, Leong DC, Buckley NA (2005) Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C. Ann Pharmacother 39(9):1566–1569 (Sep)
  69. Bonati A (1991) How and why should we standardize phytopharmaceutical drugs for clinical validation? J Ethnopharmacol 32(1–3):195–197 (Apr)
  70. Calabrese EJ (1979) Conjoint use of laetrile and megadoses of ascorbic acid in cancer treatment: possible side effects. Med Hypotheses 5(9):995–997 (Sep)
  71. Calabrese EJ (1979) Possible side effects from treatment with laetrile. Med Hypotheses 5(9):1045–1049 (Sept)
  72. Hwang EY, Lee JH, Lee YM, Hong SP (2002) Reverse-phase HPLC separation of d-amygdalin and neoamygdalin and optimum conditions for inhibition of racemization of amygdalin. Chem Pharm Bull (Tokyo) 50(10):1373–1375 (Oct)
  73. Hu S, Yuan D, Diao GF, Bi KS, Kano Y (2002) Studies on evaluation of Semen Armeniacae amarum. Zhongguo Zhong Yao Za Zhi 27(10):736–739 (Oct)
  74. Krebs ET Jr, Krebs ET Sr, Beard HH (1950) The unitarian or trophoblastic thesis of cancer. Med Rec 163(7):149–174
  75. Gal EM, Fung FH, Greenberg DM (1952) Studies on the biological action of malononitriles, II: distribution of rhodanese (transulfurase) in the tissues of normal and tumor-bearing animals and the effect of malononitriles thereon. Cancer Res 12:574–579
  76. Conchie J., Findlay June, Levvy G. A., Mammalian glycosidases. Distribution in the body, 10.1042/bj0710318
  77. Fishman WH (1955) Beta-glucoronidase. Adv Enzymol Relat Subj Bioch 16:361–409
  78. Krebs ET Jr (1970) The nitrilosides (vitamin B17)—their nature, occurrence and metabolic significance antineoplastic vitamin B17. J Appl Nutr 22:75–86
  79. Donaldson MS (2004) Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 3(1):19 (Oct 20)
  80. Young VR, Newberne PM (1981) Vitamins and cancer prevention: issues and dilemmas. Cancer 47(Suppl 5):1226–1240 (Mar 1)
  81. Sakamoto Shinobu, Yoshino Haruo, Shirahata Yaeko, Shimodairo Kazuo, Okamoto Ryohei, Pharmacotherapeutic Effects of Kuei-chih-fu-ling-wan (Keishi-bukuryo-gan) on Human Uterine Myomas, 10.1142/s0192415x92000333
Bibliographic reference Milazzo, Stefania ; Lejeune, Stephane ; Ernst, Edzard. Laetrile for cancer: a systematic review of the clinical evidence. In: Supportive Care in Cancer, Vol. 15, no. 6, p. 583-595 (2007)
Permanent URL http://hdl.handle.net/2078.1/37484