User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient

Primary tabs

Andrei, G. Goubau, Patrick [UCL] Fiten, P. van Landuyt, H. Gordts, B. De Clercq, Etienne [UCL] Snoeck, R.

A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype.

Document type Article de périodique (Journal article) – Case Reports, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2007
Language Anglais
Journal information "Transplant Infectious Disease" - Vol. 9, no. 2, p. 126-31 (2007)
Peer reviewed yes
Publisher Blackwell Publishing (Oxford)
issn 1398-2273
e-issn 1399-3062
Publication status Publié
Affiliations UCL - (SLuc) Service de microbiologie
UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - MD/ESP - Ecole de santé publique
MESH Subject Tumor Virus Infections - complications - drug therapy ; Polyomavirus Infections - complications - drug therapy ; Phosphonic Acids - therapeutic use ; Humans ; Herpesvirus 1, Human - isolation & purification ; Herpes Simplex - complications - drug therapy ; Female ; Drug Resistance, Viral ; Cytosine - analogs & derivatives - therapeutic use ; Bone Marrow Transplantation - adverse effects ; BK Virus ; Antiviral Agents - therapeutic use ; Adolescent ; Acyclovir - therapeutic use
Keywords polyomaviruses ; herpesviruses ; resistance ; cidofovir ; hemorrhagic cystitis ; stem cell transplant
Links
  1. Longerich Thomas, Eisenbach Christoph, Penzel Roland, Kremer Thomas, Flechtenmacher Christa, Helmke Burkhard, Encke Jens, Kraus Thomas, Schirmacher Peter, Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy, 10.1002/lt.20567
  2. Morfin Florence, Thouvenot Danielle, Herpes simplex virus resistance to antiviral drugs, 10.1016/s1386-6532(02)00263-9
  3. Levin Myron J., Bacon Teresa H., Leary Jeffry J., Resistance of Herpes Simplex Virus Infections to Nucleoside Analogues in HIV‐Infected Patients, 10.1086/422364
  4. Springer K. L., Chou S., Li S., Giller R. H., Quinones R., Shira J. E., Weinberg A., How Evolution of Mutations Conferring Drug Resistance Affects Viral Dynamics and Clinical Outcomes of Cytomegalovirus-Infected Hematopoietic Cell Transplant Recipients, 10.1128/jcm.43.1.208-213.2005
  5. Baldanti Fausto, Lurain Nell, Gerna Giuseppe, Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs, 10.1016/j.humimm.2004.02.007
  6. Andrei Graciela, Snoeck Robert, Fiten Pierre, De Clercq Erik, Opdenakker Ghislain, Esnouf Robert, Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene, 10.1099/0022-1317-81-3-639
  7. Muller W. J., Levin M. J., Shin Y. K., Robinson C., Quinones R., Malcolm J., Hild E., Gao D., Giller R., Clinical and In Vitro Evaluation of Cidofovir for Treatment of Adenovirus Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients, 10.1086/498151
  8. Clercq Erik De, Holý Antonín, Case history: Acyclic nucleoside phosphonates: a key class of antiviral drugs, 10.1038/nrd1877
  9. Snoeck R, Curr Opin Investig Drugs, 3, 1561 (2002)
  10. De Clercq E., Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections, 10.1128/cmr.16.4.569-596.2003
  11. Seber A, Shu X O, Defor T, Sencer S, Ramsay N, Risk factors for severe hemorrhagic cystitis following BMT, 10.1038/sj.bmt.1701523
  12. Cesaro S, Brugiolo A, Faraci M, Uderzo C, Rondelli R, Favre C, Zecca M, Garetto G, Dini G, Pillon M, Messina C, Zanesco L, Pession A, Locatelli F, Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: a survey from the Italian association of pediatric hematology oncology–bone marrow transplantation group, 10.1038/sj.bmt.1704252
  13. Leung A Y H, Yuen K-Y, Kwong Y-L, Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm, 10.1038/sj.bmt.1705139
  14. Kuypers Dirk R.J., Vandooren Ann-Karolien, Lerut Evelyne, Evenepoel Pieter, Claes Kathleen, Snoeck Robert, Naesens Lieve, Vanrenterghem Yves, Adjuvant Low-Dose Cidofovir Therapy for BK Polyomavirus Interstitial Nephritis in Renal Transplant Recipients, 10.1111/j.1600-6143.2005.00980.x
  15. Gorczynska Ewa, Turkiewicz Dominik, Rybka Katarzyna, Toporski Jacek, Kalwak Krzysztof, Dyla Agnieszka, Szczyra Zofia, Chybicka Alicja, Incidence, Clinical Outcome, and Management of Virus-Induced Hemorrhagic Cystitis in Children and Adolescents after Allogeneic Hematopoietic Cell Transplantation, 10.1016/j.bbmt.2005.06.007
  16. Suzutani T., Ishioka K., De Clercq E., Ishibashi K., Kaneko H., Kira T., Hashimoto K.-i., Ogasawara M., Ohtani K., Wakamiya N., Saijo M., Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir, 10.1128/aac.47.5.1707-1713.2003
  17. Andrei G., Balzarini J., Fiten P., De Clercq E., Opdenakker G., Snoeck R., Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin, 10.1128/jvi.79.9.5863-5869.2005
  18. Saijo M., Suzutani T., Morikawa S., Kurane I., Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain, 10.1128/aac.49.2.606-611.2005
  19. Snoeck R., Andrei G., Gerard M., Silverman A., Hedderman A., Balzarini J., Sadzot-Delvaux C., Tricot G., Clumeck N., De Clercq E., Successful Treatment of Progressive Mucocutaneous Infection Due to Acyclovirand Foscarnet-Resistant Herpes Simplex Virus with (S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine (HPMPC), 10.1093/clinids/18.4.570
  20. Sarisky R. T., Quail M. R., Clark P. E., Nguyen T. T., Halsey W. S., Wittrock R. J., Bartus J. O'L., Van Horn M. M., Sathe G. M., Van Horn S., Kelly M. D., Bacon T. H., Leary J. J., Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir, 10.1128/jvi.75.4.1761-1769.2001
  21. Blot N, Schneider P, Young P, Janvresse C, Dehesdin D, Tron P, Vannier J P, Treatment of an acyclovir and foscarnet-resistant herpes simplex virus infection with cidofovir in a child after an unrelated bone marrow transplant, 10.1038/sj.bmt.1702591
  22. Larder BA, EMBO J, 6, 169 (1987)
  23. Foster SA, J Biol Chem, 5, 238 (1991)
Bibliographic reference Andrei, G. ; Goubau, Patrick ; Fiten, P. ; van Landuyt, H. ; Gordts, B. ; et. al. Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient. In: Transplant Infectious Disease, Vol. 9, no. 2, p. 126-31 (2007)
Permanent URL http://hdl.handle.net/2078.1/37672