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Efficient and selective deprotection method for N-protected 2(3H)-benzoxazolones and 2(3H)-benzothiazolones

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Carato, Pascal Yous, Saïd Sellier, Didier Poupaert, Jacques [UCL] Lebegue, Nicolas Berthelot, Pascal

Cyclic carbamate flanked with heterocyclic or aliphatic moieties are frequently used in medicinal chemistry. The synthesis of derivatives bearing a free NH often requires the use of a protection method. A literature search reveals very few protection/deprotection methods for cyclic carbamates. In this paper, we described different methods applicable to 2(3H)-benzoxazolone and 2(3H)-benzothiazolone. (C) 2004 Elsevier Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2004
Language Anglais
Journal information "Tetrahedron" - Vol. 60, no. 45, p. 10321-10324 (2004)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0040-4020
e-issn 1464-5416
Publication status Publié
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords 2(3H)-benzoxazolone ; 2(3H)-benzothiazolone ; protecting groups
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Bibliographic reference Carato, Pascal ; Yous, Saïd ; Sellier, Didier ; Poupaert, Jacques ; Lebegue, Nicolas ; et. al. Efficient and selective deprotection method for N-protected 2(3H)-benzoxazolones and 2(3H)-benzothiazolones. In: Tetrahedron, Vol. 60, no. 45, p. 10321-10324 (2004)
Permanent URL http://hdl.handle.net/2078.1/39917