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Synthesis of C5-substituted imidazolines

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Defacqz, N Van, TT. Cordi, A. Marchand-Brynaert, Jacqueline [UCL]

5-(Hydroxymethyl)-3-(t-butyloxycarbonyl)imidazoline 2 was prepared in four steps from 2,3-diaminopropionic acid in 72% overall yield. Mitsunobu reaction with a series of phenol derivatives gave the corresponding 5-(aryloxymethyl)-3-(t-butyloxycarbonyl)imidazolines 8a-1. Phthalimide and N-benzyl trifluoroacetamide also reacted. (C) 2003 Elsevier Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Language Anglais
Journal information "Tetrahedron Letters" - Vol. 44, no. 51, p. 9111-9114 (2003)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0040-4039
e-issn 1873-3581
Publication status Publié
Affiliation UCL
Keywords imidazoline ; Mitsunobu reaction
Links
Bibliographic reference Defacqz, N ; Van, TT. ; Cordi, A. ; Marchand-Brynaert, Jacqueline. Synthesis of C5-substituted imidazolines. In: Tetrahedron Letters, Vol. 44, no. 51, p. 9111-9114 (2003)
Permanent URL http://hdl.handle.net/2078.1/40638