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Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: Report from an international workshop

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Block, AnneMarie W. Carroll, Andrew J. Hagemeijer, Anne Michaux, Lucienne [UCL] van Lom, Kirsten Baer, Maria R.

Seventy-seven patients were identified with Rare recurring (excluding 11q23, 21q22, inv(16), and t(15; 17)) chromosome abnormalities among 511 patients with treatment-related myelodysplastic syndromes and acute leukemia accepted from centers in the United States, Europe, and Japan. The abnormality subsets included 3q21q26 (17 patients), 11p15 (17 patients), t(9;22)(q34;q 11) (10 patients), 12p13 (9 patients), t(8; I 6)(p11;p13) (9 patients), and an "other" subset, which included t(6;9)(p23;q34) (3 patients), t(10;11)(p13;q13similar toq21) (3 patients), t(1;17)(p36;q21) (2 patients), t(8; 14)(q24;q32) (2 patients), t(11;19)(q13;q13) (2 patients), t(1;3)(p36;q21) (2 patients), and t(3;5)(q21;q31) (1 patient). Increased karyotypic complexity with additional balanced and unbalanced rearrangements was observed in 70% of cases. Among 54 cases with secondary abnormalities, chromosome 5 and/or 7 abnormalities were observed in 59%. The most frequent primary diseases were breast cancer (24 cases), Hodgkin disease (14 cases), non-Hodgkin lymphoma (10 cases), and De novo ALL (5 cases). Thirty-seven patients received alkylating agents plus topoisomerase 11 inhibitors with or without radiation therapy, The presenting diagnosis was t-AML in 47 cases, t-MDS in 23 cases (10 progressed to t-AML), and t-ALL in seven cases, five of whom had a t(9;22). The median latency time from initiation of original therapy to therapy-related disease diagnosis was quite long (69 months), and the overall median survival from the date of therapy-related disease diagnosis was very short (7 months). The 1-year survival rate was 34 +/- 7%, with no significant differences among subsets. Comparison with previously reported cases showed increased karyotypic complexity and adult presentation of pediatric-associated chromosome abnormalities. (C) 2002 Wiley-Liss, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2002
Language Anglais
Journal information "Genes, Chromosomes & Cancer" - Vol. 33, no. 4, p. 401-412 (2002)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 1045-2257
e-issn 1098-2264
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hématologie
MESH Subject Translocation, Genetic - drug effects - genetics ; Neoplasm Recurrence, Local - chemically induced - epidemiology ; Myelodysplastic Syndromes - chemically induced - epidemiology ; Middle Aged ; Male ; Leukemia, Myeloid, Acute - chemically induced - epidemiology ; Humans ; Female ; Chromosome Aberrations - chemically induced - statistics & numerical data ; Child ; Aged ; Adult ; Adolescent
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Bibliographic reference Block, AnneMarie W. ; Carroll, Andrew J. ; Hagemeijer, Anne ; Michaux, Lucienne ; van Lom, Kirsten ; et. al. Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: Report from an international workshop. In: Genes, Chromosomes & Cancer, Vol. 33, no. 4, p. 401-412 (2002)
Permanent URL http://hdl.handle.net/2078.1/42113