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HOMA-modelling of insulin sensitivity and beta-cell function in anorexia nervosa

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Hermans, Michel P. [UCL] Lambert, Michel J. [UCL]

In order to assess insulin sensitivity (IS) and beta-cell function (B) in anorexia nervosa (AN) we measured fasting plasma glucose (FPG), immunoreactive insulin and C-peptide levels in 33 consecutive subjects with AN for modelling with Homeostasis Model Assessment (HOMA.). Mean (+/-1 SD) fasting glucose and insulin levels were 71+/-10 mg dl(-1) and 7.3+/-2.8 muU ml(-1) respectively. Median IS and B (% normal) were 143 (percentile 25-75: 95-194) and 127 (102-157). When subjects were stratified according, to median IS, those with high insulin sensitivity were of similar age, AN duration, weight, BMI, and body composition to those with normal IS. However, FPG was significantly lower in the higher insulin sensitivity subgroup (67+/-11 versus 75+/-7 mg dl(-1); P<0.03), and two patients presented with symptomatic hypoglycaemia. We conclude that patients with AN exhibit a trend toward increased IS, which is not associated with any specific clinical characteristic. In the whole cohort, B was either normal or moderately increased. Copyright (C) 2002 John Wiley & Sons, Ltd and Eating Disorders Association.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2002
Language Anglais
Journal information "European Eating Disorders Review" - Vol. 10, no. 1, p. 41-50 (2002)
Peer reviewed yes
Publisher John Wiley & Sons Ltd (W Sussex)
issn 1072-4133
e-issn 1099-0968
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/FSIO - Département de physiologie et pharmacologie
UCL - (SLuc) Service d'endocrinologie et de nutrition
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
Keywords anorexia nervosa ; insulin sensitivity ; beta-cell function ; HOMA
Links
  1. ABUBAKARE A, TROPICAL OR MALNUTRITION-RELATED DIABETES: A REAL SYNDROME?, 10.1016/s0140-6736(86)91846-5
  2. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders (4th edn), APA: Washington DC.
  3. Casper Regina C., Carbohydrate metabolism and its regulatory hormones in anorexia nervosa, 10.1016/0165-1781(96)02984-8
  4. CASTILLO M., SCHEEN A., LEFEBVRE P.J., LUYCKX A.S., Insulin-Stimulated Glucose Disposal Is not Increased in Anorexia Nervosa*, 10.1210/jcem-60-2-311
  5. Franssila-Kallunki Anja, Rissanen Aila, Ekstrand Agneta, Eriksson Johan, Saloranta Carola, Widén Elisabeth, Schalin-Jäntti Camilla, Groop Leif, Fuel metabolism in anorexia nervosa and simple obesity, 10.1016/0026-0495(91)90085-b
  6. Fukushima M., Nakai Y., Taniguchi A., Imura H., Nagata I., Tokuyama K., Insulin sensitivity, insulin secretion, and glucose effectiveness in anorexia nervosa: A minimal model analysis, 10.1016/0026-0495(93)90275-s
  7. Hermans, Acta Clinica Belgica, 53, 379 (1998)
  8. Hermans M. P., Levy J. C., Morris R. J., Turner R. C., Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes, 10.1007/s001250051215
  9. Hermans M. P., Levy J. C., Morris R. J., Turner R. C., Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes, 10.2337/diabetes.48.9.1779
  10. Hosker J. P., Matthews D. R., Rudenski A. S., Burnett M. A., Darling P., Bown E. G., Turner R. C., Continuous infusion of glucose with model assessment: measurement of insulin resistance and ?-cell function in man, 10.1007/bf00280882
  11. Kiriike N., Nishiwaki S., Nagata T., Okuno Y., Yamada J., Tanaka S., Fujii A., Kawakita Y., Insulin sensitivity in patients with anorexia nervosa and bulimia, 10.1111/j.1600-0447.1990.tb06487.x
  12. Lambert Michel, Hubert Catherine, Depresseux Genevi�ve, Vande Berg Bruno, Thissen Jean-Paul, de Deuxchaisnes Charles Nagant, Devogelaer Jean-Pierre, Hematological changes in anorexia nervosa are correlated with total body fat mass depletion, 10.1002/(sici)1098-108x(1997)21:4<329::aid-eat4>3.0.co;2-q
  13. Levy, Diabetes, 44, 89a (1995)
  14. Levy J. C., Matthews D. R., Hermans M. P., Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program, 10.2337/diacare.21.12.2191
  15. Levy J. C., Rudenski A., Burnett M., Knight R., Matthews D. R., Turner R. C., Simple empirical assessment of Beta-cell function by a constant infusion of glucose test in normal and Type 2 (non-insulin-dependent) diabetic subjects, 10.1007/bf00403285
  16. Maki Kevin C., Abraira Carlos, Correspondence, 10.1016/0026-0495(94)90089-2
  17. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C., Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man, 10.1007/bf00280883
  18. Nozaki, Journal of Clinical Endocrinology and Metabolism, 79, 217 (1994)
  19. Porte Jr. D., Seeley R. J., Woods S. C., Baskin D. G., Figlewicz D. P., Schwartz M. W., Obesity, diabetes and the central nervous system, 10.1007/s001250051002
  20. RAO R. HARSHA, Diabetes in the Undernourished: Coincidence or Consequence?, 10.1210/edrv-9-1-67
  21. Scheen A. J., Castillo M., Lefèbvre P. J., Insulin sensitivity in anorexia nervosa: A mirror image of obesity?, 10.1002/dmr.5610040705
  22. 1993. Measurement of insulin resistance and Beta-cell function: the HOMA and CIGMA approach. In Current Topics in Diabetes Research, (eds). Karger: Basel.
  23. Woods, American Journal of Clinical Nutrition, 42, 1063 (1985)
  24. Zuniga-Guajardo S., Garfinkel P.E., Zinman B., Changes in insulin sensitivity and clearance in anorexia nervosa, 10.1016/0026-0495(86)90021-1
Bibliographic reference Hermans, Michel P. ; Lambert, Michel J.. HOMA-modelling of insulin sensitivity and beta-cell function in anorexia nervosa. In: European Eating Disorders Review, Vol. 10, no. 1, p. 41-50 (2002)
Permanent URL http://hdl.handle.net/2078.1/42326