Cagnon, José Renato
[UCL]
Le Bideau, Franck
[UCL]
Marchand-Brynaert, Jacqueline
[UCL]
Ghosez, Léon
[UCL]
Ketenes have been found to cycloadd with (R)-2-tert-Butyldihydrooxazole 1 and 2 to yield predominantly regioisomers 4 resulting from steric control rather than electronic control. The cycloadditions provide a practical route to enantiomerically pure protected 2-amino-3-hydroxycyclobutanones. (C) 1997 Elsevier Science Ltd.
Bibliographic reference |
Cagnon, José Renato ; Le Bideau, Franck ; Marchand-Brynaert, Jacqueline ; Ghosez, Léon. Unusual regiochemistry of cycloaddition of ketenes to (R)-2-tert-butyldihydrooxazole derivatives. A simple route towards enantiomerically pure functionalised alpha-aminocyclobutanones.. In: Tetrahedron Letters, Vol. 38, no. 13, p. 2291-2294 (1997) |
Permanent URL |
http://hdl.handle.net/2078.1/46377 |