Gaspar, R.
Préat, Véronique
[UCL]
Roland, Marie
[UCL]
Nanoparticles of polyisohexylcyanoacrylate with bound primaquine were prepared by an emulsion polymerization method and an i.v. formulation was obtained after freeze-drying. Such formulation is intended for drug targeting in visceral leishmaniasis. Drug binding seemed largely dependent on pH and formulation conditions were optimized to obtain a polymeric colloidal suspension containing particles in the 200-250 nm size range and 80-90% drug binding (final content of 10 mg of drug per vial). Aspects such as polymer-drug interaction, in vitro drug release and physicochemical stability were studied. A significant reduction in acute toxicity was demonstrated by using the targeted formulation in NMRI mice.
Bibliographic reference |
Gaspar, R. ; Préat, Véronique ; Roland, Marie. Nanoparticles of Polyisohexylcyanoacrylate (pihca) As Carriers of Primaquine - Formulation, Physicochemical Characterization and Acute Toxicity. In: International Journal of Pharmaceutics, Vol. 68, no. 1-3, p. 111-119 (1991) |
Permanent URL |
http://hdl.handle.net/2078.1/51222 |