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Hepatic-clearance of Gitoxin - Pharmacokinetic Study On Rabbit Isolated Liver - Influence of Protein-binding and Comparison With Digoxin

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Pellegrin, P. Lesne, Michel [UCL]
Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1983
Language Anglais
Journal information "European Journal of Drug Metabolism and Pharmacokinetics" - Vol. 8, no. 1, p. 1-8 (1983)
Peer reviewed yes
Publisher Medecine Et Hygiene (Geneva 4)
issn 0378-7966
Publication status Publié
Affiliation UCL
Links
  1. Lesne, M. (1978): Pharmacological reevaluation of gitoxin in man. Int. J. Clin. Pharmacol.16, 456–459.
  2. Hupin, C., Desuray, J.M., Versluys, J., Lorent, M., Dodion, L. and Lesne, M. (1979): Bioavailability study of gitoxin in a solid dosage form. Int. J. Clin. Pharmacol. Biopharm.17, 197–204.
  3. Verbeke, N., Pellegrin, P., Vienne, A., Lesne, M. (1979): The binding of gitoxin to human plasma proteins. Eur. J. Clin. Pharmacol.16, 341–344.
  4. Dolphen, R. and Lesne, M. (1980): Uptake and pharmacological effect of gitoxin and gitaloxin in rat and guinea-pig perfused hearts. Comparison with digitoxin and digoxin. Arzneim. Forsch./Drug Res.30, 614–618.
  5. Lesne, M., van Ypersele, Ch. and Vanderbroecke, J.M. (1977): Etude pré;iminaire de la pharmacocinétique de la gitoxine dans l’insuffisance rénale. J. Pharmacol. (Paris)8, 552.
  6. Lesne, M. and Dolphen, R. (1976): Development of an original radioimmunoassay for gitoxin and gitoxin derivatives. J. Pharmacol. (Paris)7, 619–626.
  7. Rowland, M., Benet, L.Z. and Graham, G.G. (1973): Clearance concepts in pharmacokinetics. J. Pharmacokin Biopharm.1, 123–136.
  8. Kadima, L.N. and Lesne, M. (1980): Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of3H-gitoxin. Arch. Int. Pharmacodyn. Ther.245, 20–41.
  9. Shand, D.G., Kornhouser, D.M. and Wilkinson, G.R. (1975): Effect of route of administration and blood flow on hepatic drug elimination. J. Pharmacol. Exp. Ther.195, 424–432.
  10. Shand, D.G., Cotham, R.H. and Wilkinson, G.R. (1976): Perfusion-limited effects of plasma drug binding on hepatic drug extraction. Life Sci.19, 125–130.
  11. Lage, G.L. and Spratt, J.L. (1968): Species and sex variations in the hepatic metabolism of3H-digoxin in vitro. J. Pharmacol. Exp. Ther.159, 182–193.
  12. KOLENDA K.-D., LÜLLMANN H., PETERS T., SEILER K.-U., Plasma concentration, uptake by liver, and biliary excretion of tritiated cardiac glycosides in the isolated perfused guinea-pig liver, 10.1111/j.1476-5381.1971.tb07073.x
  13. Rietbrock, N., Abshagen, U., Bergmann, K.V. and Kewitz, H. (1972): Pharmacokinetics of digoxin and its 4′″-acetyl- and methylderivates in the rat. Naunyn-Schmiedeberg’s Arch. Pharmacol.274, 171–181.
  14. Abshagen, U., Bergmann, K.V. and Rietbrock, N. (1972): Evaluation of the enterohepatic circulation after3H-digoxin administration in the rat. Naunyn-Schmiedeberg’s Arch. Pharmacol.275, 1–10.
  15. Russell, J.Q. and Klaassen, C.D. (1973): Biliary excretion of cardiac glycosides. J. Pharmacol. Exp. Ther.186, 455–462.
  16. Ochs, H.R., Bodem, G., Bales, G., Greenblatt, D.J. and Smith, T.W. (1978): Increased clearance of digoxin in rabbits during repeated administration. J. Pharmacol. Exp. Ther.204, 262–270.
  17. Kawamura, J., Sato, H., Kimura, T., Tokunaga, H., Mitani, K. and Fukuda, H. (1975): Serum digoxin concentration after oral administration of digoxin in rabbits. I. Eisei Shikenjo Hokoku93, 61–65.
  18. Höller, M. and Breuer, H. (1975): The effect of fluorocarbon FC43 on the metabolism of steroids during perfusion of the isolated rat liver. Z. Clin. Chem. Klin. Biochem.13, 319–323.
Bibliographic reference Pellegrin, P. ; Lesne, Michel. Hepatic-clearance of Gitoxin - Pharmacokinetic Study On Rabbit Isolated Liver - Influence of Protein-binding and Comparison With Digoxin. In: European Journal of Drug Metabolism and Pharmacokinetics, Vol. 8, no. 1, p. 1-8 (1983)
Permanent URL http://hdl.handle.net/2078.1/56769