Renauld, Jean-Christophe
[UCL]
Class II cytokine receptors were originally defined on the basis of sequence homologies in the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and the ligands, known as class II cytokines, also have a common structure. More recently, a series of new receptors and cytokines that belong to this family have been discovered. The therapeutic potential of the 'old' members of this family, IFNs and IL-1, is recognized in the clinic, and the existence of structurally related molecules is raising expectations for additional clinical applications. In this review, I discuss both structural and biological data that are emerging about this family of receptors and ligands, to highlight the potential applications of modulating the activity of these cytokines.
Bibliographic reference |
Renauld, Jean-Christophe. Class II cytokine receptors and their ligands : key antiviral and inflammatory modulators.. In: Nature Reviews. Immunology, Vol. 3, no. 8, p. 667-676 (2003) |
Permanent URL |
http://hdl.handle.net/2078.1/83947 |