Préat, Véronique
[UCL]
The use of a low intensity current (iontophoresis) and high voltage pulses (electroporation which permeabilizes lipid bilayers) has a potential for the administration of conventional and biotechnology-produced drugs. Iontophoresis and electroporation enhance transdermal delivery of drugs, including peptides and oligonucleotides. Electrochemotherapy, i.e., combination of a systemic or local delivery of a non-permeant cytostatic drug with electroporation, kills locally tumor cells. Recently, it has been shown that the local injection of a plasmid before electroporation increases significantly gene transfection. Hence, electrotransfer is a promising alternative for drug and gene delivery.
Bibliographic reference |
Préat, Véronique. Administration de médicaments et de gènes par électrotransfert.. In: Annales pharmaceutiques françaises, Vol. 59, no. 4, p. 239-44 (2001) |
Permanent URL |
http://hdl.handle.net/2078.1/8894 |