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The intestinal nuclear receptor signature with epithelial localization patterns andexpression modulation in tumors.

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Modica, Salvatore Gofflot, Françoise [UCL] Murzilli, Stefania D'Orazio, Andria Salvatore, Lorena Moschetta, Antonio

The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors functioning as sensors of hormones and nutrients that are known to contribute to colon cancer progression. Here we mapped the messenger RNA (mRNA) abundance and the epithelial localization of the entire nuclear receptor family in mouse and human intestine.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Gastroenterology" - Vol. 138, no. 2, p. 636-48, 648.e1-12 (2010)
Peer reviewed yes
issn 0016-5085
Publication status Publié
Affiliations UCL - SST/ISV - Institut des sciences de la vie
UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology
MESH Subject Adenoma - metabolism, pathology ; Adenomatous Polyposis Coli - metabolism, pathology ; Gene Expression Profiling ; Humans ; Ileum - metabolism, pathology ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Messenger - metabolism ; Receptors, Cytoplasmic and Nuclear - genetics, metabolism ; Young Adult ; Adolescent ; Adult ; Animals ; Colon - metabolism, pathology ; Colonic Neoplasms - metabolism, pathology ; Disease Models, Animal ; Epithelial Cells - metabolism, pathology ; Female
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Bibliographic reference Modica, Salvatore ; Gofflot, Françoise ; Murzilli, Stefania ; D'Orazio, Andria ; Salvatore, Lorena ; et. al. The intestinal nuclear receptor signature with epithelial localization patterns andexpression modulation in tumors.. In: Gastroenterology, Vol. 138, no. 2, p. 636-48, 648.e1-12 (2010)
Permanent URL http://hdl.handle.net/2078.1/90397