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Management of hepatic metastasis from colorectal cancers: an update.

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Sharma, Sharad Camci, Cemalettin Jabbour, Nicolas [UCL]

Approximately 50%-60% of patients with colorectal cancers will develop liver lesions in their life span. Despite the potential of surgical resection to provide long-term survival in this subset of patients, only 15%-20% are found to be resectable. The introduction of new neoadjuvant chemotherapeutic agents and the expanding criteria of resection have enhanced the overall 5-year survival from 30% to 60% in the past decade. The use of technical innovations such as staged resection; portal vein embolization, and repeat resection have allowed higher resection rates in patients with bilobar disease. Extrahepatic primary and liver-exclusive recurrent disease no longer represent an absolute contraindication to resection. The role of regional therapy using hepatic arterial infusion is being redefined for liver-exclusive unresectable disease. Adjuvant chemotherapy in combination with regional therapies is being looked at from fresh perspectives. Ablative approaches have gained a firm role both as an adjunct to surgical resection and in the management of patients who are not surgical candidates. Overall, the management of hepatic metastasis from colorectal cancers requires a multimodal approach.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2008
Language Anglais
Journal information "Journal of Hepato-Biliary-Pancreatic Surgery" - Vol. 15, no.6, p. 570-580 (2008)
Peer reviewed yes
Publisher Springer Japan KK
issn 0944-1166
e-issn 1436-0691
Publication status Publié
Affiliation INTEGRIS Baptist Medical Center, Oklahoma City, USA - Nazih Zudhi Transplant Institute
MESH Subject Antineoplastic Agents ; Laparoscopy ; Liver Neoplasms ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Catheter Ablation ; Chemotherapy, Adjuvant ; Chemotherapy, Cancer, Regional Perfusion ; Colorectal Neoplasms ; Combined Modality Therapy ; Diagnostic Imaging ; Embolization, Therapeutic ; Humans
Keywords Hepatic ; Metastasis ; Colorectal ; Cancer
Links
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Bibliographic reference Sharma, Sharad ; Camci, Cemalettin ; Jabbour, Nicolas. Management of hepatic metastasis from colorectal cancers: an update.. In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 15, no.6, p. 570-580 (2008)
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