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Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion

MPG-Autoren
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Gündüz,  S
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Vibhute,  SM
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

http://pubs.rsc.org/en/content/articlepdf/2014/cc/c4cc07540d
(Verlagsversion)

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Zitation

Gündüz, S., Nitta, N., Vibhute, S., Shibata, S., Maier, M., Logothetis, N., et al. (2015). Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion. Chemical Communications, 51(14), 2782-2785. doi:10.1039/C4CC07540D.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-4789-F
Zusammenfassung
We report a methodology which enables preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaken synthetic transformations, despite structural changes. The in vivo MRI studies in rat cerebral cortex indicate that diffusion property of dendrimeric contrast agent has great advantages as compared to its monomeric equivalent.