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Journal Article

A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane

MPS-Authors
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Brod,  Florian
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fässler,  Reinhard
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fulltext (public)

embj.2020106234.pdf
(Publisher version), 205KB

Supplementary Material (public)

10.15252-embj.2020106234Figure20201062340001.ppt
(Supplementary material), 592KB

Citation

Brod, F., & Fässler, R. (2020). A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane. EMBO Journal, e106234. doi:10.15252/embj.2020106234.


Cite as: https://hdl.handle.net/21.11116/0000-0007-14EE-7
Abstract
Focal adhesion kinase (FAK) is a central mediator of cell adhesion, acting both as a scaffold and as catalytically active kinase. Acebronet al(2020) use cryo-electron microscopy (cryo-EM) to visualize the dramatic structural changes that occur uponFAKrecruitment to the plasma membrane, which releasesFAKautoinhibition and induces its oligomerization. Since activity control via autoinhibition and protein clustering are features also utilized by other focal adhesion (FA) proteins, they have moved center stage in the endeavor to understand the complex process of cell adhesion regulation.