Reply to: "Levodopa‐induced dyskinesia are mediated by cortical gamma 
oscillations in experimental Parkinsonism"

Güttler, Christopher; Altschüler, Jennifer; Tanev, Kaloyan; Böckmann, Saskia; Haumesser, Jens Kersten; Nikulin, Vadim V.; Kühn, Andrea A.; Riesen, Christoph

doi:10.1002/mds.28576

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Reply to: "Levodopa‐induced dyskinesia are mediated by cortical gamma oscillations in experimental Parkinsonism"

MPS-Authors

/persons/resource/persons201758

Nikulin, Vadim V.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Güttler, C., Altschüler, J., Tanev, K., Böckmann, S., Haumesser, J. K., Nikulin, V. V., et al. (2021). Reply to: "Levodopa‐induced dyskinesia are mediated by cortical gamma oscillations in experimental Parkinsonism". Movement Disorders, 36(4), 1045-1047. doi:10.1002/mds.28576.

Cite as: https://hdl.handle.net/21.11116/0000-0008-6ED9-9

Abstract

Background

Levodopa is the most efficacious drug in the symptomatic therapy of motor symptoms in Parkinson's disease (PD); however, long‐term treatment is often complicated by troublesome levodopa‐induced dyskinesia (LID). Recent evidence suggests that LID might be related to increased cortical gamma oscillations.
Objective

The objective of this study was to test the hypothesis that cortical high‐gamma network activity relates to LID in the 6‐hydroxydopamine model and to identify new biomarkers for adaptive deep brain stimulation (DBS) therapy in PD.
Methods

We recorded and analyzed primary motor cortex (M1) electrocorticogram data and motor behavior in freely moving 6‐OHDA lesioned rats before and during a daily treatment with levodopa for 3 weeks. The results were correlated with the abnormal involuntary movement score (AIMS) and used for generalized linear modeling (GLM).
Results

Levodopa reverted motor impairment, suppressed beta activity, and, with repeated administration, led to a progressive enhancement of LID. Concurrently, we observed a highly significant stepwise amplitude increase in finely tuned gamma (FTG) activity and gamma centroid frequency. Whereas AIMS and FTG reached their maximum after the 4th injection and remained on a stable plateau thereafter, the centroid frequency of the FTG power continued to increase thereafter. Among the analyzed gamma activity parameters, the fraction of longest gamma bursts showed the strongest correlation with AIMS. Using a GLM, it was possible to accurately predict AIMS from cortical recordings.
Conclusions

FTG activity is tightly linked to LID and should be studied as a biomarker for adaptive DBS.