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Journal Article

Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes

MPS-Authors
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Neumann,  Gunnar U.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Tukhbatova,  Rezeda I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Krause,  Johannes
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Pfrengle, S., Neukamm, J., Guellil, M., Keller, M., Molak, M., Avanzi, C., et al. (2021). Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes. BMC Biology, 19(1): 220. doi:10.1186/s12915-021-01120-2.


Cite as: https://hdl.handle.net/21.11116/0000-0009-79CC-A
Abstract
Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significantly improve our understanding of the disease’s complex history. Previous studies have identified a high genetic continuity of the pathogen over the last 1500 years and the existence of at least four M. leprae lineages in some parts of Europe since the Early Medieval period.