Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression 
and Bipolar Disorder to Cognitive Decline

Hansen, N; Singh, A; Bartels, C; Brosseron, F; Buerger, K; Cetindag , AC; Dobisch, L; Dechent, P; Ertl-Wagner, BB; Fliessbach, K; Haynes, JD; Heneka, MT; Janowitz, D; Kilimann, I; Laske, C; Metzger, CD; Munk, MH; Peters, O; Priller, J; Roy, N; Scheffler, K; Schneider, A; Spottke, A; Spruth, EJ; Teipel, S; Tscheuschler, M; Vukovich, R; Wiltfang, J; Duezel, E; Jessen, F; Goya-Maldonado, R

doi:10.3389/fnagi.2021.626974

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

MPS-Authors

/persons/resource/persons84187

Scheffler, K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://www.frontiersin.org/articles/10.3389/fnagi.2021.626974/pdf
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Hansen, N., Singh, A., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A., et al. (2021). Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Frontiers in Aging Neuroscience, 13: 626974, pp. 1-12. doi:10.3389/fnagi.2021.626974.

Cite as: https://hdl.handle.net/21.11116/0000-0009-F320-0

Abstract

Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.