Changes in occipital GABA, glutamate/glutamine concentrations and cerebral 
oxygen metabolism in response to visual stimulation

Chan, KL; Lu, H; Lin, Z; Henning, A; Thomas, BP

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Meeting Abstract

Changes in occipital GABA, glutamate/glutamine concentrations and cerebral oxygen metabolism in response to visual stimulation

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Henning, A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://archive.ismrm.org/2022/0307.html
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Citation

Chan, K., Lu, H., Lin, Z., Henning, A., & Thomas, B. (2022). Changes in occipital GABA, glutamate/glutamine concentrations and cerebral oxygen metabolism in response to visual stimulation. In Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting (ISMRM 2022).

Cite as: https://hdl.handle.net/21.11116/0000-000A-5CBE-A

Abstract

The relationship between brain’s GABA and glutamate/glutamine (Glx) concentrations measured by 1H MRS, hemodynamic response, neural signaling, and behavior is poorly understood. Here, the relationship between MRS-detectable GABA and Glx signals and MR hemodynamic contrasts during visual stimulation were examined. It was observed that changes in GABA+ and Glx were positively correlated with the BOLD response and negatively correlated with their levels at rest. Additionally, task GABA+ concentrations were negatively correlated with cerebral metabolic rate of oxygen (CMRO2). Together, these results suggest shifts in the inhibitory/excitatory balance and metabolism to maintain homeostasis in the brain.