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Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients
Title: | Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients |
Authors: | Oyama, Naotsugu Browse this author | Urasawa, Kazushi Browse this author | Kaneta, Satoshi Browse this author | Sakai, Hidetsugu Browse this author | Saito, Takahiko Browse this author | Takagi, Chika Browse this author | Yoshida, Ichiro Browse this author | Kitabatake, Akira Browse this author | Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Keywords: | ACE inhibitor | Congestive heart failure | G protein-coupled receptor kinase |
Issue Date: | Mar-2006 |
Publisher: | The Japanese Circulation Society |
Journal Title: | Circulation Journal |
Volume: | 70 |
Issue: | 3 |
Start Page: | 362 |
End Page: | 363 |
Publisher DOI: | 10.1253/circj.70.362 |
PMID: | 16501306 |
Abstract: | Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. (Circ J 2006; 70: 362 - 363) |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/17015 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 筒井 裕之
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