| Title: | Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology Study Group |
| Authors: | Onozawa, Masahiro Browse this author |
| Hashino, Satoshi Browse this author |
| Haseyama, Yoshifumi Browse this author |
| Hirayama, Yasuo Browse this author |
| Iizuka, Susumu Browse this author |
| Ishida, Tadao Browse this author |
| Kaneda, Makoto Browse this author |
| Kobayashi, Hajime Browse this author |
| Kobayashi, Ryoji Browse this author |
| Koda, Kyuhei Browse this author |
| Kurosawa, Mitsutoshi Browse this author |
| Mosauji, Nobuo Browse this author |
| Matsunaga, Takuya Browse this author |
| Mori, Akio Browse this author |
| Mukai, Masaya Browse this author |
| Nishio, Mitsufumi Browse this author |
| Noto, Satoshi Browse this author |
| Ota, Shuichi Browse this author |
| Sakai, Hajime Browse this author |
| Suzuki, Nobuhiro Browse this author |
| Takahashi, Tohru Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Torimoto, Yoshihiro Browse this author |
| Yoshida, Makoto Browse this author |
| Fukuhara, Takashi Browse this author |
| Keywords: | Varicella zoster virus |
| Postherpetic neuralgia |
| Disseminated zoster |
| Visceral zoster |
| Issue Date: | Jun-2009 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 15 |
| Issue: | 6 |
| Start Page: | 724 |
| End Page: | 729 |
| Publisher DOI: | 10.1016/j.bbmt.2009.03.003 |
| PMID: | 19450757 |
| Abstract: | To assess the incidence of and risk factors associated with post-herpetic neuralgia (PHN) after post-hematopoietic cell transplantation (HCT) varicella-zoster virus (VZV) infection, we conducted a retrospective chart review of 418 consecutive patients who underwent HCT between April 2005 and March 2007. Male/female ratio was 221/197, median age at HCT was 47 years (range: 0-69 years), and autologous/allogeneic/syngeneic HCT ratio was 154/263/1. Seventy-eight patients developed VZV infection after HCT. Sixty-two patients had localized zoster, 11 patients had disseminated zoster (rash like chicken pox), and 4 patients had visceral zoster. All cases were treated with acyclovir (ACV) or valacyclovir (VACV), and there was no VZV infection-related death. Twenty-seven (35%) of the 78 patients with VZV infection suffered PHN after resolution of VZV infection. Multivariate analysis showed that advanced age is the only risk factor in autologous HCT (P = 0.0075; OR = 1.14; 95% Cl, 0.97 to 1.33). On the other hand, advanced age (P = 0.0097; OR = 1.06; 95% Cl, 1.01 to 1.12), male gender (P = 0.0055; OR = 12.7; 95% Cl, 1.61 to 100.1), and GVHD prophylaxis with a tacrolimus-based regimen (P = 0.0092; OR = 9.56; 95% Cl, 1.44 to 63.3) were associated with increased risk of PHN in allogeneic HCT. This study for the first time clarified the risk of PHN in HCT recipients. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/38728 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
