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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
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Title: | Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. |
Authors: | Hata, Saori Browse this author →KAKEN DB | Taniguchi, Miyako Browse this author →KAKEN DB | Piao, Yi Browse this author | Ikeuchi, Takeshi Browse this author | Fagan, Anne M Browse this author | Holtzman, David M Browse this author | Bateman, Randall Browse this author | Sohrabi, Hamid R Browse this author | Martins, Ralph N Browse this author | Gandy, Sam Browse this author | Urakami, Katsuya Browse this author →KAKEN DB | Suzuki, Toshiharu Browse this author →KAKEN DB |
Issue Date: | 2012 |
Publisher: | BioMed Central |
Journal Title: | Molecular neurodegeneration |
Volume: | 7 |
Start Page: | 16 |
Publisher DOI: | 10.1186/1750-1326-7-16 |
PMID: | 22534039 |
Abstract: | Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP or Alcα by α- and γ-secretases generates non-aggregatable p3 or p3-Alcα peptides. Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD). |
Rights: | http://creativecommons.org/licenses/by/3.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/51698 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 鈴木 利治
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