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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine
| Title: | A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine |
| Authors: | Shinoki, Aki Browse this author | | Lang, Weeranuch Browse this author | | Thawornkuno, Charin Browse this author | | Kang, Hee-Kwon Browse this author | | Kumagai, Yuya Browse this author | | Okuyama, Masayuki Browse this author →KAKEN DB | | Mori, Haruhide Browse this author →KAKEN DB | | Kimura, Atsuo Browse this author →KAKEN DB | | Ishizuka, Satoshi Browse this author →KAKEN DB | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | α-1,6-Glucosaccharide | | Quercetin glycoside | | Absorption | | Rats |
| Issue Date: | 15-Jan-2013 |
| Publisher: | Elsevier |
| Journal Title: | Food Chemistry |
| Volume: | 136 |
| Issue: | 2 |
| Start Page: | 293 |
| End Page: | 296 |
| Publisher DOI: | 10.1016/j.foodchem.2012.08.028 |
| PMID: | 23122060 |
| Abstract: | The presence of α-1,6-glucosaccharide enhances absorption of water-soluble quercetin glycosides, a mixture of quercetin-3-O-β-D-glucoside (Q3G, 31.8%), mono (23.3%), di (20.3%) and more D-glucose adducts with α-1,4-linkage to D-glucose moiety of Q3G, in a ligated small intestinal loop of anesthetized rats. We enzymatically prepared α-1,6-glucosaccharides with different degrees of polymerization (DP) and separated them into a megaloisomaltosaccharide-containing fraction (M-IM, average DP = 11.0) and an oligoisomaltosaccharide-containing fraction (O-IM, average DP = 3.6). Luminal injection of either saccharide fractions promoted the absorption of total quercetin-derivatives from the small intestinal segment and this effect was greater for M-IM than O-IM addition. M-IM also increased Q3G, but not the quercetin aglycone, concentration in the water-phase of the luminal contents more strongly than O-IM. The enhancement of Q3G solubilization in the luminal contents may be responsible for the increases in the quercetin glucoside absorption promoted by α-1,6-glucosaccharides, especially M-IM. These results suggest that the ingestion of α-1,6-glucosaccharides promotes Q3G bioavailability. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52124 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 篠木 亜季
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