|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas
| Title: | Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas |
| Authors: | Sakashita, Tomohiro Browse this author →KAKEN DB | | Homma, Akihiro Browse this author →KAKEN DB | | Suzuki, Seigo Browse this author →KAKEN DB | | Hatakeyama, Hiromitsu Browse this author →KAKEN DB | | Kano, Satoshi Browse this author →KAKEN DB | | Mizumachi, Takatsugu Browse this author | | Oridate, Nobuhiko Browse this author →KAKEN DB | | Fukuda, Satoshi Browse this author →KAKEN DB |
| Keywords: | Immunohistochemistry | | local recurrence | | head and neck cancer |
| Issue Date: | Sep-2013 |
| Publisher: | Informa |
| Journal Title: | Acta oto-laryngologica |
| Volume: | 133 |
| Issue: | 9 |
| Start Page: | 984 |
| End Page: | 991 |
| Publisher DOI: | 10.3109/00016489.2013.795287 |
| PMID: | 23692432 |
| Abstract: | Conclusion: It was proved that cyclin D1-positive status in surgical margins was an independent prognostic indicator of local recurrence. The expression of cyclin D1 in tumor-free surgical margins may better predict local recurrence in patients with head and neck squamous cell carcinoma (HNSCC) after surgical treatment with curative intent. Objective: This retrospective study aimed to determine the prognostic indicators for local recurrence in HNSCC. Methods: A total of 116 HNSCC patients who underwent surgical treatment with curative intent and had histopathologically tumor-free margins were eligible for this study. The expression of p53 and cyclin D1 was assessed by immunohistochemical staining in surgical margins as well as in tumor specimens. Results: In all, 63 patients (54.3%) had p53-positive tumor specimens and 34 patients (29.3%) had p53-positive margins. Seventy-six patients (65.6%) had cyclin D1-positive tumor specimens and 54 patients (46.6%) had cyclin D1-positive margins. A significant difference in local control rates was observed between patients with cyclin D1-positive and -negative margins (77.2% vs 91.5%, log rank test, p = 0.0139). Multivariate Cox proportional hazards testing indicated that the hazard ratio of cyclin D1-positive margins for local recurrence was 4.58 (95% confidence interval 1.14–21.69, p = 0.0304). |
| Rights: | Copyright (c) Informa |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57076 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 坂下 智博
|
