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The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
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Title: | The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring |
Authors: | Yanagiya, Shingo Browse this author | Cho, Kyu Yong Browse this author | Nakamura, Akinobu Browse this author →KAKEN DB | Nomoto, Hiroshi Browse this author | Kawamoto, Yasuyuki Browse this author | Kawakubo, Kazumichi Browse this author →KAKEN DB | Komatsu, Yoshito Browse this author →KAKEN DB | Mitsuhashi, Tomoko Browse this author →KAKEN DB | Miyoshi, Hideaki Browse this author →KAKEN DB | Atsumi, Tatsuya Browse this author →KAKEN DB |
Keywords: | everolimus | hypoglycemia | continuous glucose monitoring |
Issue Date: | 1-Sep-2018 |
Publisher: | The Japanese Society of Internal Medicine |
Journal Title: | Internal medicine |
Volume: | 57 |
Issue: | 17 |
Start Page: | 2527 |
End Page: | 2531 |
Publisher DOI: | 10.2169/internalmedicine.0126-17 |
Abstract: | An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed that her blood glucose levels were maintained without hypoglycemia throughout the day. Furthermore, everolimus reduced the duration of time above the upper limit (>180 mg/dL) along with the standard deviation and mean amplitude of glycemic excursions. This case shows the potential effects of everolimus on hypoglycemia and glycemic control in a patient with inoperable metastatic insulinoma evaluated by CGM. |
Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/71863 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 中村 昭伸
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