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Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors
| Title: | Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors |
| Authors: | Sugiura, Ryo Browse this author | | Kuwatani, Masaki Browse this author →KAKEN DB | | Kawakubo, Kazumichi Browse this author →KAKEN DB | | Sano, Itsuki Browse this author | | Kato, Shin Browse this author | | Endo, Tomoyuki Browse this author | | Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Endoscopic sphincterotomy | | Hemophilia | | Choledocholithiasis |
| Issue Date: | Jun-2018 |
| Publisher: | Springer |
| Journal Title: | Clinical journal of gastroenterology |
| Volume: | 11 |
| Issue: | 3 |
| Start Page: | 188 |
| End Page: | 192 |
| Publisher DOI: | 10.1007/s12328-018-0826-8 |
| PMID: | 29396835 |
| Abstract: | Endoscopic sphincterotomy (ES) is a standard procedure for bile duct stone removal. However, the safety of ES in patients with hemophilia remains unknown. We treated a 46-year-old man who had choledocholithiasis and severe hemophilia A with high-responding inhibitors during immune tolerance induction therapy. Since coagulation factor VIII inhibitors neutralize and inactivate endogenous and exogenous factor VIII, bleeding risk is higher in hemophilia A patients with inhibitors than in those without inhibitors. With adequate pre- and post-procedure monitoring of the clotting factor and supplemented clotting factor, the patient could safely undergo ES without bleeding complications. ES can be also an effective and safe first-line therapy for choledocholithiasis in patients with hemophilia and inhibitors under the condition of appropriate management. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/74503 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 桒谷 将城
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