| Title: | Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study |
| Authors: | Kobayashi, Sumitaka Browse this author →KAKEN DB |
| Sata, Fumihiro Browse this author |
| Murata, Katsuyuki Browse this author →KAKEN DB |
| Saijo, Yasuaki Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Itoh, Sachiko Browse this author →KAKEN DB |
| Minatoya, Machiko Browse this author →KAKEN DB |
| Yamazaki, Keiko Browse this author →KAKEN DB |
| Ait Bamai, Yu Browse this author →KAKEN DB |
| Kishi, Reiko Browse this author →KAKEN DB |
| Kawamoto, Toshihiro Browse this author |
| Saito, Hirohisa Browse this author |
| Yaegashi, Nobuo Browse this author |
| Hashimoto, Koichi Browse this author |
| Mori, Chisato Browse this author |
| Itoh, Shuichi Browse this author |
| Yamagata, Zentaro Browse this author |
| Inadera, Hidekuni Browse this author |
| Kamijima, Michihiro Browse this author |
| Nakayama, Takeo Browse this author |
| Iso, Hiroyasu Browse this author |
| Shima, Masayuki Browse this author |
| Hirooka, Yasuaki Browse this author |
| Suganuma, Narufumi Browse this author |
| Kusuhara, Koichi Browse this author |
| Katoh, Takahiko Browse this author |
| Keywords: | birthweight |
| caffeine |
| pregnancy |
| preterm birth |
| small for gestational age |
| the Japan Environment and Children's Study |
| Issue Date: | May-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Paediatric and Perinatal Epidemiology |
| Volume: | 33 |
| Issue: | 3 |
| Start Page: | 185 |
| End Page: | 194 |
| Publisher DOI: | 10.1111/ppe.12551 |
| Abstract: | Background: Few previous studies have investigated the association between prenatal caffeine intake and birth size (small-for-gestational-age (SGA), preterm birth, and birthweight Z-score) in Japan. Objectives: We examined the dose-dependency of this association (prenatal caffeine consumption and birth size) as part of the Japan Environment and Children’s Study. Methods: A prospective birth cohort included 94,876 fetuses in Japan. Participants were enrolled between January 2011 and March 2014. Adjusted multiple linear regression and Cox regression models were used to examine the association between prenatal caffeine levels and infant birth size. Results: The median estimated caffeine consumption during pregnancy was 125.5 mg/day, as determined by self-administered questionnaires. There were 7,252 SGA infants (7.6%) and 4,281 preterm birth infants (4.5%). Compared with infants of mothers whose caffeine consumption during pregnancy was in the lowest quartile (4.2 to <86.4 mg/day), infants of mothers whose caffeine consumption was in the highest quartile 4 (205.5 to 5,080.0 mg/day) were at an increased risk of SGA (relative risk [RR]: 1.18; 95% confidence interval [CI]: 1.10, 1.27), and at an increased risk of preterm birth at the 2nd trimester of gestation (RR: 1.94; 95% CI: 1.12, 3.37), with a 0.32-day reduction in gestational age (95% CI: -0.52, -0.12) and with a 0.07 reduction in birthweight Z-score observed (95% CI: -0.09, -0.05). Conclusions: Prenatal caffeine consumption was associated with birth size. However, as the association between prenatal caffeine consumption and birth size was likely 5 confounded by unpredicted potential factors, our confidence in the true causality of the association is moderate. |
| Rights: | This is the peer reviewed version of the following article: Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study: Paediatric and perinatal epidemiology: 33(3), 185-194, 2019, which has been published in final form at https://doi.org/10.1111/ppe.12551. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/77805 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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