| Title: | The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis |
| Authors: | Sajiki, Yamato Browse this author |
| Konnai, Satoru Browse this author →KAKEN DB |
| Nagata, Reiko Browse this author |
| Kawaji, Satoko Browse this author →KAKEN DB |
| Nakamura, Hayato Browse this author |
| Fujisawa, Sotaro Browse this author |
| Okagawa, Tomohiro Browse this author →KAKEN DB |
| Maekawa, Naoya Browse this author →KAKEN DB |
| Kato, Yukinari Browse this author →KAKEN DB |
| Suzuki, Yasuhiko Browse this author →KAKEN DB |
| Murata, Shiro Browse this author →KAKEN DB |
| Mori, Yasuyuki Browse this author |
| Ohashi, Kazuhiko Browse this author →KAKEN DB |
| Keywords: | cattle |
| immunotherapy |
| Johne's disease |
| programmed death-ligand 1 |
| Th1 response |
| Issue Date: | Feb-2021 |
| Publisher: | 公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science) |
| Journal Title: | Journal of veterinary medical science |
| Volume: | 83 |
| Issue: | 2 |
| Start Page: | 162 |
| End Page: | 166 |
| Publisher DOI: | 10.1292/jvms.20-0590 |
| Abstract: | Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteritis of ruminants. Previous studies have shown that programmed death-ligand 1 (PD-L1) is associated with the disease progression, and PD-L1 blockade activates MAP-specific Th1 responses in vitro. Here, we performed anti-PD-L1 antibody administration using 2 MAP-infected cattle at the late subclinical stage of infection. After administration, bacterial shedding was reduced or maintained at a low level. Additionally, MAP-specific Th1 cytokine production was upregulated, and CD69 expression was increased in T cells. Collectively, the treatment has a potential as a novel control method against Johne's disease. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81959 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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