| Title: | Determination of brain tumor recurrence using C-11-methionine positron emission tomography after radiotherapy |
| Authors: | Yamaguchi, Shigeru Browse this author |
| Hirata, Kenji Browse this author |
| Okamoto, Michinari Browse this author |
| Shimosegawa, Eku Browse this author |
| Hatazawa, Jun Browse this author |
| Hirayama, Ryuichi Browse this author |
| Kagawa, Naoki Browse this author |
| Kishima, Haruhiko Browse this author |
| Oriuchi, Noboru Browse this author |
| Fujii, Masazumi Browse this author |
| Kobayashi, Kentaro Browse this author |
| Kobayashi, Hiroyuki Browse this author |
| Terasaka, Shunsuke Browse this author |
| Nishijima, Ken-ichi Browse this author |
| Kuge, Yuji Browse this author |
| Ito, Yoichi M. Browse this author |
| Nishihara, Hiroshi Browse this author |
| Tamaki, Nagara Browse this author |
| Shiga, Tohru Browse this author |
| Keywords: | brain tumors |
| methionine |
| positron emission tomography |
| radiation injuries |
| recurrences |
| Issue Date: | 1-Oct-2021 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Cancer science |
| Volume: | 112 |
| Issue: | 10 |
| Start Page: | 4246 |
| End Page: | 4256 |
| Publisher DOI: | 10.1111/cas.15001 |
| Abstract: | We conducted a prospective multicenter trial to compare the usefulness of C-11-methionine (MET) and F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) for identifying tumor recurrence. Patients with clinically suspected tumor recurrence after radiotherapy underwent both C-11-MET and F-18-FDG PET. When a lesion showed a visually detected uptake of either tracer, it was surgically resected for histopathological analysis. Patients with a lesion negative to both tracers were revaluated by magnetic resonance imaging (MRI) at 3 months after the PET studies. The primary outcome measure was the sensitivity of each tracer in cases with histopathologically confirmed recurrence, as determined by the McNemar test. Sixty-one cases were enrolled, and 56 cases could be evaluated. The 38 cases where the lesions showed uptake of either C-11-MET or F-18-FDG underwent surgery; 32 of these cases were confirmed to be subject to recurrence. Eighteen cases where the lesions showed uptake of neither tracer received follow-up MRI; the lesion size increased in one of these cases. Among the cases with histologically confirmed recurrence, the sensitivities of C-11-MET PET and F-18-FDG PET were 0.97 (32/33, 95% confidence interval [CI]: 0.85-0.99) and 0.48 (16/33, 95% CI: 0.33-0.65), respectively, and the difference was statistically significant (P < .0001). The diagnostic accuracy of C-11-MET PET was significantly better than that of F-18-FDG PET (87.5% vs. 69.6%, P = .033). No examination-related adverse events were observed. The results of the study demonstrated that C-11-MET PET was superior to F-18-FDG PET for discriminating between tumor recurrence and radiation-induced necrosis. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82974 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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