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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
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Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina
| Title: | Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina |
| Authors: | Kageyama, Hiroyuki Browse this author | | Morita, Koichi Browse this author | | Katoh, Chietsugu Browse this author | | Tsukamoto, Takahiro Browse this author | | Noriyasu, Kazuyuki Browse this author | | Mabuchi, Megumi Browse this author | | Naya, Masanao Browse this author | | Kawai, Yuko Browse this author | | Tamaki, Nagara9 Browse this author →KAKEN DB |
| Authors(alt): | 玉木, 長良9 |
| Keywords: | 123I-BMIPP | | Myocardial flow reserve | | Substrate shift | | Long-chain fatty acid metabolism |
| Issue Date: | 25-Jul-2005 |
| Publisher: | Springer-Verlag GmbH |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 33 |
| Issue: | 1 |
| Start Page: | 6 |
| End Page: | 12 |
| Publisher DOI: | 10.1007/s00259-005-1863-3 |
| PMID: | 16041617 |
| Abstract: | Purpose Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest, but in ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123I-BMIPP is a radiolabeled LCFA analog. In chronic stable angina without previous infarction, we suppose that reduced 123I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). The purpose of this study was to relate 123I-BMIPP uptake to rest myocardial blood flow (MBF), hyperemic MBF, and MFR assessed with 15O-water positron emission tomography (PET).
Methods We enrolled 21 patients with chronic stable angina without previous infarction, all of whom underwent 123I-BMIPP single-photon emission computed tomography (SPECT) and 15O-water PET. The left ventricle was divided into 13 segments. In each segment, rest MBF and hyperemic MBF were measured by PET. 123I-BMIPP uptake was evaluated as follows: score 0=normal, 1=slightly decreased uptake, 2=moderately decreased uptake, 3=severely decreased uptake, and 4=complete defect. 123I-BMIPP uptake was compared with rest MBF, hyperemic MBF, and MFR.
Results The numbers of segments with 123I-BMIPP scores 0, 1, 2, 3, and 4 were 178, 40, 25, 24, and 0, respectively. The rest MBFs for scores 0, 1, 2, and 3 were 0.93±0.25, 0.86±0.21, 0.97±0.30, and 0.99±0.37 ml/min/g, respectively. The hyperemic MBFs for scores 0, 1, 2, and 3 were 2.76±1.29, 1.84±0.74, 1.37±0.39, and 1.08±0.40 ml/min/g, respectively. The MFRs for scores 0, 1, 2, and 3 were 3.01±1.38, 2.20±0.95, 1.44±0.22, and 1.10±0.26, respectively. As 123I-BMIPP uptake declined, hyperemic MBF and MFR decreased.
Conclusion In chronic stable angina without previous infarction, reduced 123I-BMIPP uptake implies decreased MFR. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/923 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉木 長良
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