Relating structural and functional anomalous connectivity in the aging brain via neural mass modeling
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10.1016/j.neuroimage.2009.12.105
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hdl:2117/10294
Tipus de documentArticle
Data publicació2010-09
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Abstract
The structural changes that arise as the brain ages influence its functionality. In many cases, the anatomical
degradation simply leads to normal aging. In others, the neurodegeneration is large enough to cause
neurological disorders (e.g. Alzheimer's disease). Structure and function can be both currently measured using
noninvasive techniques, such as magnetic resonance imaging (MRI) and electroencephalography (EEG)
respectively. However, a full theoretical scheme linking structural and functional degradation is still lacking.
Here we present a neural mass model that aims to bridge both levels of description and that reproduces
experimentally observed multichannel EEG recordings of alpha rhythm in young subjects, healthy elderly
subjects, and patients with mild cognitive impairment. We focus our attention in the dominant frequency of
the signals at different electrodes and in the correlation between specific electrode pairs, measured via the
phase-lag index. Our model allows us to study the influence of different structural connectivity pathways,
independently of each other, on the normal and aberrantly aging brain. In particular, we study in detail the
effect of the thalamic input on specific cortical regions, the long-range connectivity between cortical regions,
and the short-range coupling within the same cortical area. Once the influence of each type of connectivity is
determined, we characterize the regions of parameter space compatible with the EEG recordings of the
populations under study. Our results show that the different types of connectivity must be fine-tuned to
maintain the brain in a healthy functioning state independently of its age and brain condition.
CitacióPons, A. J. [et al.]. Relating structural and functional anomalous connectivity in the aging brain via neural mass modeling. "Neuroimage", Setembre 2010, vol. 52, núm. 3, p. 848-861.
ISSN1053-8119
Versió de l'editorhttp://www.ncbi.nlm.nih.gov/pubmed/20056154
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