Journal Article

FZJ-2017-08292

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png MRI biomarkers of proximal nerve injury in CIDP

Lichtenstein, T. ; Sprenger, A. ; Weiss, K. ; Slebocki, K. ; Cervantes, B. ; Karampinos, D. ; Maintz, D. ; Fink, G. R.FZJ* ; Henning, T. D. ; Lehmann, H. C. (Corresponding author)

2018
Wiley Chichester [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/16596  doi:10.1002/acn3.502

Abstract: ObjectiveTo evaluate the utility of nerve diffusion tensor imaging (DTI), nerve cross-sectional area, and muscle magnetic resonance imaging (MRI) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy (CIDP).MethodsIn this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton-density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI. Patients were longitudinally evaluated by MRI, clinical examination, and nerve conduction studies at baseline and after 6 months.ResultsIn sciatic nerves of CIDP patients, mean cross-sectional area was significantly higher and fractional anisotropy value was significantly lower, compared to controls. In contrast, muscle proton-density fat fraction was significantly higher in thigh muscles of patients with CIDP, compared to controls. MRI parameters showed high reproducibility at baseline and 6 months.InterpretationAdvanced MRI parameters demonstrate subclinical proximal nerve damage and intramuscular fat accumulation in CIDP. Data suggest DTI and multiecho Dixon MRI might be useful in estimating axonal damage and neurogenic muscle changes in CIDP.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2018

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Database coverage:
; ; ; ; DOAJ Seal ; Emerging Sources Citation Index ; NCBI Molecular Biology Database ; SCOPUS ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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