Journal Article

FZJ-2019-04956

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus

Baldermann, J. (Corresponding author) ; Hahn, L.FZJ* ; Dembek, T. ; Kohl, S. ; Kuhn, J. ; Visser-Vandewalle, V. ; Horn, A. ; Huys, D.

2019
MDPI AG Basel

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/23384  doi:10.3390/brainsci9100264

Abstract: Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential

Note: Financial disclosuresThis work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker honoraria from Boston Scientific and Medtronic. JK has received financial support for Investigator initiated trials from Medtronic. VV-V has received payments for travelling, lodging and financial compensation for contributions to advisory boards or workshops (mostly 2/year) by Medtronic, Abbott and St. Jude Medical.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)

Appears in the scientific report 2019

---

Database coverage:
; ; ; ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Emerging Sources Citation Index ; PubMed Central ; SCOPUS ; Web of Science Core Collection

---