Journal Article

FZJ-2019-03198

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Scientific Case for Brain Simulations

Einevoll, G. T. (Corresponding author) ; Destexhe, A. ; Diesmann, M.FZJ* ; Grün, S.FZJ* ; Jirsa, V. ; de Kamps, M. ; Migliore, M. ; Ness, T. V. ; Plesser, H. E.FZJ* ; Schürmann, F.

2019
Elsevier New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/23594  doi:10.1016/j.neuron.2019.03.027

Abstract: A key element of the European Union’s Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Jara-Institut Brain structure-function relationships (INM-10)
3. Theoretical Neuroscience (IAS-6)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)
2. 571 - Connectivity and Activity (POF3-571) (POF3-571)
3. HBP - The Human Brain Project (604102) (604102)
4. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)
5. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
6. DEEP-EST - DEEP - Extreme Scale Technologies (754304) (754304)
7. DFG project 322093511 - Kognitive Leistung als Ergebnis koordinierter neuronaler Aktivität in unreifen präfrontal-hippokampalen Netzwerken (322093511) (322093511)
8. HAF - Helmholtz Analytics Framework (ZT-I-0003) (ZT-I-0003)
9. Brain-Scale Simulations (jinb33_20121101) (jinb33_20121101)
10. Advanced Computing Architectures (aca_20190115) (aca_20190115)
11. GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240) (368482240)

Appears in the scientific report 2019

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Database coverage:
; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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