Book/Report

FZJ-2020-01901

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biotechnologie : Alternativmethoden zum Tierversuch : Kultivierte Herzzellen als Screening-Modell

Weber, E. (Editor)FZJ*

1988
Kernforschungsanlage Jülich GmbH Zentralbibliothek, Verlag Jülich

Please use a persistent id in citations: http://hdl.handle.net/2128/24806

Report No.: Juel-Spez-0455

Abstract: Comparative pharmacological investigations for the validationof an "in-vitro-heart-cell-model'' for the screening of cardioactivedrugs.The main objective was to assess the usability of chick embryoheart cells (HC) as a model in the screening of cardioactivecompounds in industrial drug research. Another objectivewas to assess the inf luence of computerized biosignalevaluation on aspects of animal welfare. The results of drugtesting in HC were compared to those in guinea pig isolatedright atria, papillary muscles, anesthetized rats, guineapigs, cats, dogs ans conscious dogs (reference models).In general, within the reference models the drug effects werein better correspondence than between the HC and the ref erencemodels. The number of false negative results in HC isclearly higher than in the reference models. In addition thecost-benefit relationship was unfavourable for HC. The introductionof computerized biosignal evalution for the reference models yields more extensive, more reliable, quickerand more easily accessible data and increases the sensitivityof the models.

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Contributing Institute(s):

1. Publikationen vor 2000 (PRE-2000 ; Retrocat)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

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Database coverage:

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