Journal Article

FZJ-2020-02654

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Coherent Fourier scatterometry reveals nerve fiber crossings in the brain

Menzel, M. (Corresponding author)FZJ* ; Pereira, S. F.

2020
OSA Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/25404  doi:10.1364/BOE.397604

Abstract: Previous simulation studies by Menzel et al. [Phys. Rev. X 10, 021002 (2020)] have shown that scattering patterns of light transmitted through artificial nerve fiber constellations contain valuable information about the tissue substructure such as the individual fiber orientations in regions with crossing nerve fibers. Here, we present a method that measures these scattering patterns in monkey and human brain tissue using coherent Fourier scatterometry with normally incident light. By transmitting a non-focused laser beam (λ = 633 nm) through unstained histological brain sections, we measure the scattering patterns for small tissue regions (with diameters of 0.1–1 mm), and show that they are in accordance with the simulated scattering patterns. We reveal the individual fiber orientations for up to three crossing nerve fiber bundles, with crossing angles down to 25°.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)

Appears in the scientific report 2020

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