Journal Article

FZJ-2021-02391

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases

Kostritskii, A. Y.FZJ* ; Machtens, J.-P. (Corresponding author)FZJ*

2021
Nature Publishing Group UK [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/27873  doi:10.1038/s41467-021-22724-w

Abstract: TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. However, their molecular mechanisms of ion conduction and selectivity remain largely unknown. Using computational electrophysiology simulations at atomistic resolution, we identified the main ion-conductive state of TMEM16 lipid scramblases, in which an ion permeation pathway is lined by lipid headgroups that directly interact with permeating ions in a voltage polarity-dependent manner. We found that lipid headgroups modulate the ion-permeability state and regulate ion selectivity to varying degrees in different scramblase isoforms, depending on the amino-acid composition of the pores. Our work has defined the structural basis of ion conduction and selectivity in TMEM16 lipid scramblases and uncovered the mechanisms responsible for the direct effects of membrane lipids on the conduction properties of ion channels.

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Contributing Institute(s):

1. Molekular- und Zellphysiologie (IBI-1)
2. JARA - HPC (JARA-HPC)

Research Program(s):

1. 524 - Molecular and Cellular Information Processing (POF4-524) (POF4-524)
2. Mechanisms of Ca2+-activated Cl- channels and lipid scramblases of the TMEM16 family (jics41_20191101) (jics41_20191101)

Appears in the scientific report 2021

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