Journal Article

FZJ-2022-02703

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Two Decades of Brain Tumour Imaging with O-(2-[18F]fluoroethyl)-L-tyrosine PET: The Forschungszentrum Jülich Experience

Heinzel, A.FZJ* ; Dedic, D. ; Galldiks, N.FZJ* ; Lohmann, P.FZJ* ; Stoffels, G.FZJ* ; Filss, C. P.FZJ* ; Kocher, M.FZJ* ; Migliorini, F. ; Dillen, K. N. H. ; Geisler, S.FZJ* ; Stegmayr, C.FZJ* ; Willuweit, A.FZJ* ; Sabel, M. ; Rapp, M. ; Eble, M. J. ; Piroth, M. ; Clusmann, H. ; Delev, D. ; Bauer, E. K. ; Ceccon, G. ; Dunkl, V. ; Rosen, J. ; Tscherpel, C. ; Werner, J.-M. ; Ruge, M. I. ; Goldbrunner, R. ; Hampl, J. ; Weiss Lucas, C. ; Herrlinger, U. ; Maurer, G. D. ; Steinbach, J. P. ; Mauler, J.FZJ* ; Worthoff, W. A.FZJ* ; Neumaier, B. N.FZJ* ; Lerche, C.FZJ* ; Fink, G. R.FZJ* ; Shah, N. J.FZJ* ; Mottaghy, F. M.FZJ* ; Langen, K.-J. (Corresponding author)FZJ*

2022
MDPI Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/31518  doi:10.3390/cancers14143336

Abstract: PET using radiolabelled amino acids has become an essential tool for diagnosing brain tumours in addition to MRI. O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is one of the most successful tracers in the field. We analysed our database of 6534 FET PET examinations regarding the diagnostic needs and preferences of the referring physicians for FET PET in the clinical decision-making process. The demand for FET PET increased considerably in the last decade, especially for differentiating tumour progress from treatment-related changes in gliomas. Accordingly, referring physicians rated the diagnostics of recurrent glioma and recurrent brain metastases as the most relevant indication for FET PET. The analysis and survey results confirm the high relevance of FET PET in the clinical diagnosis of brain tumours and support the need for approval for routine use.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Jara-Institut Quantum Information (INM-11)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)
4. Kognitive Neurowissenschaften (INM-3)
5. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2022

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