Journal Article

FZJ-2022-04652

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

Hettwer, M. D. (Corresponding author)FZJ* ; Larivière, S. ; Park, B. Y. ; van den Heuvel, O. A. ; Schmaal, L. ; Andreassen, O. A. ; Ching, C. R. K. ; Hoogman, M. ; Buitelaar, J. ; van Rooij, D. ; Veltman, D. J. ; Stein, D. J. ; Franke, B. ; van Erp, T. G. M. ; van Rooij, D. ; van den Heuvel, O. A. ; van Erp, T. G. M. ; Jahanshad, N. ; Thompson, P. M. ; Thomopoulos, S. I. ; Bethlehem, R. A. I. ; Bernhardt, B. C. ; Eickhoff, S. B.FZJ* ; Valk, S. L.FZJ*

2022
Nature Publishing Group UK [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/32599  doi:10.1038/s41467-022-34367-6

Abstract: Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

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