Contaminants of Emerging Concern in The North American Great Lakes: Evidence of Reproductive Disruption from Field and Laboratory Studies
Author(s)
Yu, Yaochun
Zhou, Li-Jun
Han, Ping
Wang, Baozhan
Men, Yujie
Wagner, Michael
Wu, Qinglong
Issue Date
2019-05-21
Keyword(s)
endocrine disrupting compounds
pharmaceuticals
Abstract
Sulfonamides (SAs) as one of the biggest families of antibiotics are widely used as human and animal drugs. The detection of sulfonamide antibiotics in natural environments raises emerging concerns about the potential risks of these contaminants to ecosystems and public health. Previous studies have demonstrated that ammonia oxidizers were able to biotransform many emerging organic contaminants. Here, to better understand the roles of ammonia oxidizers in sulfonamides biotransformation, we investigated the biotransformation capability of Nitrospira inopinata (complete ammonia-oxidizing bacteria), Nitrososphaera gargensis (ammonia-oxidizing archaea) and Nitrosomonas nitrosa Nm90 (ammonia-oxidizing bacteria) for 7 sulfonamide antibiotics (i.e. sulfadiazine, sulfadoxine, sulfamethazine, sulfamethoxazole, sulfamonomethoxine, sulfamerazine, sulfathiazole). The removals and protein-normalized biotransformation rate constants indicated that N. gargensis exhibited the highest SA biotransformation rates, followed by N. inopinata and then N. nitrosa Nm90. The transformation products of sulfadiazine, sulfamethazine, and sulfamethoxazole and the biotransformation mechanisms were also evaluated. Details will be presented during the conference.
Series/Report Name or Number
2019 Emerging Contaminants in the Environment Conference (ECEC19)
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