Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic

Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S.; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn P.; Chalmers, Don; Chan, Sarah; Charlesworth, Jac; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne L.; Hewitt, Alex W.; Kamens, Joanne; Kato, Kazuto; Kleiderman, Erika; Kodama, Satoshi; Liddicoat, John; Mackey, David A.; Newson, Ainsley J.; Nielsen, Jane; Wagner, Jennifer K.; McWhirter, Rebekah E.

Permalink

https://hdl.handle.net/2142/110383 Copy

Description

Title

Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic

Author(s)

• Nicol, Dianne
• Eckstein, Lisa
• Morrison, Michael
• Sherkow, Jacob S.
• Otlowski, Margaret
• Whitton, Tess
• Bubela, Tania
• Burdon, Kathryn P.
• Chalmers, Don
• Chan, Sarah
• Charlesworth, Jac
• Critchley, Christine
• Crossley, Merlin
• de Lacey, Sheryl
• Dickinson, Joanne L.
• Hewitt, Alex W.
• Kamens, Joanne
• Kato, Kazuto
• Kleiderman, Erika
• Kodama, Satoshi
• Liddicoat, John
• Mackey, David A.
• Newson, Ainsley J.
• Nielsen, Jane
• Wagner, Jennifer K.
• McWhirter, Rebekah E.

Issue Date

2017-09-25

Keyword(s)

• Somatic Cell Therapy
• Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)
• Genome Editing
• Stakeholder Engagement Mechanisms

Abstract

Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.

Publisher

Genome Medicine

Type of Resource

sound

Language

en

Permalink

http://hdl.handle.net/2142/110383

DOI

10.1186/s13073-017-0475-4

Owning Collections