University of Illinois Urbana-Champaign

Genome-wide association study of persistent developmental stuttering

Kraft, Shelly Jo

Content Files
1_Kraft_ShellyJo.pdf

Permalink

https://hdl.handle.net/2142/17054

Description

Title
Genome-wide association study of persistent developmental stuttering
Author(s)
Kraft, Shelly Jo
Issue Date
2010-08-31T20:30:43Z
Director of Research (if dissertation) or Advisor (if thesis)
  • Ambrose, Nicoline G.
  • Cox, Nancy J.
Doctoral Committee Chair(s)
Ambrose, Nicoline G.
Committee Member(s)
  • Cox, Nancy J.
  • Yairi, Ehud
  • DeThorne, Laura S.
  • Ceman, Stephanie S.
Department of Study
Speech & Hearing Science
Discipline
Speech & Hearing Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2010-08-31T20:30:43Z
Keyword(s)
  • Stuttering
  • Genome-wide association study (GWAS)
  • Genetics
Abstract
A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who persistently stutter, to identify common genetic variants among these people when contrasted to the general population of matched ethnicity. Eighty-four affected subjects, ages 13 to 70 years, of northern European ancestry and 107 matched controls were investigated to identify replicable candidate genes that influence the risk of individuals to stutter. The results associated 10 significant candidate genes with persistent developmental stuttering. In addition, the pathways in which these genes function to potentially disrupt the fluent production of speech were investigated. Functional significance was found with relevance to three functional categories pertaining to neural development, neural function, and behavior. Many of the genes were also found to be implicated in other known neurological, behavioral, and speech and language disorders.
Graduation Semester
2010-08
Permalink
http://hdl.handle.net/2142/17054
Copyright and License Information
Copyright 2010 Shelly Jo Kraft

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Speech and Hearing Science